Psychology Commons^™

Multidimensional Frequency Domain Analysis Of Full-Volume Fmri Reveals Significant Effects Of Age, Gender, And Mental Illness On The Spatiotemporal Organization Of Resting-State Brain Activity, Robyn L. Miller, Erik B. Erhardt, Oktay Agcaoglu, Elena A. Allen, Andrew M. Michael, Jessica Turner, Juan Bustillo, Judith M. Ford, Daniel H. Mathalon, Theo G. M. Van Erp, Steven G. Potkin, Adrian Preda, Godfrey Pearlson, Vince D. Calhoun

Psychology Faculty Publications

Clinical research employing functional magnetic resonance imaging (fMRI) is often conducted within the connectionist paradigm, focusing on patterns of connectivity between voxels, regions of interest (ROIs) or spatially distributed functional networks. Connectivity-based analyses are concerned with pairwise correlations of the temporal activation associated with restrictions of the whole-brain hemodynamic signal to locations of a priori interest. There is a more abstract question however that such spatially granular correlation-based approaches do not elucidate: Are the broad spatiotemporal organizing principles of brains in certain populations distinguishable from those of others? Global patterns (in space and time) of hemodynamic activation are rarely scrutinized …

Fkbp5 Modulates Attention Bias For Threat: Associations With Hippocampal Function And Morphology, Negar Fani, David Gutman, Erin Tone, Lynn Almli, Kristina B. Mercer, Jennifer Davis, Ebony Glover, Tanja Jovanovic, Bekh Bradley, Ivo D. Dinov, Alen Zamanyan, Arthur W. Toga, Elisabeth B. Binder, Kerry J. Ressler

Psychology Faculty Publications

Context: The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamicpituitary‐adrenal axis functioning, and has been associated with a number of stress‐related psychiatric disorders. The study of intermediate phenotypes, such as emotion‐processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates psychopathology risk.

Objective: To examine whether allelic variations for a putatively functional SNP associated with FKBP5 gene regulation (rs1360780) would relate differentially to attentional bias for threat; this was measured through behavioral response on a dot probe task and hippocampal activation during task performance. Morphological substrates of differential hippocampal response …

Neural Responses To Feedback Regarding Betrayal And Cooperation In Adolescents With Anxiety And Mood Disorders, Erin B. Tone

Psychology Faculty Publications

This study examined patterns of neural response to feedback regarding betrayal and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and neural activation patterns during the Prisoner’s Dilemma (PD) game, an economic exchange task involving betrayal and cooperation, between age- and IQ-matched groups of adolescents with anxiety/depressive disorders (A/D) (N=13) and healthy controls (n=17). Participants were deceived to believe that their co-player (a pre-programmed computer algorithm) was another study participant. Although participants responded similarly following feedback that the co-player had cooperated with them on preceding trials, A/D adolescents were more likely than controls to cooperate …

Behavioral And Neural Representation Of Emotional Facial Expressions Across The Lifespan, Leah Somerville, Fani Negar, Erin Tone

Psychology Faculty Publications

Humans’ experience of emotion and comprehension of affective cues varies substantially across the lifespan. Work in cognitive and affective neuroscience has begun to characterize behavioral and neural responses to emotional cues that systematically change with age. This review examines work to date characterizing the maturation of facial expression comprehension, and dynamic changes in amygdala recruitment from early childhood through late adulthood while viewing facial expressions of emotion. Recent neuroimaging work has tested amygdala and prefrontal engagement in experimental paradigms mimicking real aspects of social interactions, which we highlight briefly, along with considerations for future research.

Neural Circuitry Engaged During Unsuccessful Motor Inhibition In Pediatric Bipolar Disorder, Ellen Leibenluft, Brendan A. Rich, Deborah T. Vinton, Eric E. Nelson, Stephen J. Fromm, Lisa H. Berghorst, Paramijit Joshi, Adelaide Robb, Russell J. Schachar, Daniel P. Dickstein, Erin Tone, Daniel S. Pine

Psychology Faculty Publications

Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder (BPD). Therefore, studies of the neural circuitry engaged during failed motor inhibition in pediatric BPD may contribute to our understanding of the pathophysiology of the illness. We tested the hypothesis that children with BPD and controls would differ in ventral prefrontal cortex (vPFC), striatal, and anterior cingulate activation during unsuccessful motor inhibition. We also compared activation in medicated vs. unmedicated children with BPD, and in children with BPD and ADHD (BPD+ADHD) vs. those with BPD but without ADHD (BPD-ADHD).

Method: Event-related fMRI study comparing …