Psychology Commons^™

Cognitive Impairment No Dementia And Associations With Health Literacy, Self-Management Skills, And Functional Health Status, Derin J. Cobia, Rebecca M. Lovett, Laura M. Curtis, Stephen D. Persell, James W. Griffith, Alex Federman, Michael S. Wolf

Faculty Publications

Objectives: To determine the prevalence of cognitive impairment no dementia (CIND) among a diverse, community-based population, and establish associations between CIND and health literacy, chronic disease self-management and functional health status.

Methods: 863 primary care adults without dementia aged 55–74. Adjusted logistic and linear regressions were used to assess associations between CIND (None, Mild, Moderate/Severe) and outcomes.

Results: 36% participants exhibited CIND. It was strongly associated with limited health literacy (Newest Vital Signs: Mild [OR 3.25; 95% CI 1.93, 5.49], Moderate/Severe [OR 6.45; 95% CI 3.16, 13.2]; Test of Functional Health Literacy in Adults: Mild [OR 3.46; 95% CI 2.08, …

Greater Memory Impairment In Dementing Females Than Males Relative To Sex Matched Healthy Controls, Shawn D. Gale, Leslie Baxter, Juliann Thompson

Faculty Publications

Previously we demonstrated sex differences in episodic memory in healthy elderly and suggested that normative data be separated by sex. The present study extended the exploration of sex differences on memory measures into two clinical populations, Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Seventy-six subjects with MCI and 101 subjects with AD diagnosed by a multidisciplinary team were included. These two groups were also compared to a group of 177 healthy elderly control participants. Sex differences on the Rey Auditory Verbal Learning Test (RAVLT) (total and delayed recall) raw scores and Brief Visuospatial Memory TestRevised (BVMT-R) were demonstrated within …

Understand Psychiatric And Neurodegenerative Disorders, Derin J. Cobia

BYU Research Development Office Research Networking Conference

This research will contribute to the advancement of neuropsychology and neuroscience by elucidating the neurobiological underpinnings of psychosis and dementia.

Cognitively Normal Individuals With Ad Parents May Be At Risk For Developing Aging-Related Cortical Thinning Patterns Characteristic Of Ad, Derin J. Cobia, Katherine Reiter, Kathryn I. Alpert, Mary J. Kwasny, John C. Morris, John G. Csernansky, Lei Wang

Faculty Publications

Children of Alzheimer's Disease (AD) patients are at heightened risk of developing AD due to genetic influences, including the apolipoprotein E4 (ApoE4) allele. In this study, we assessed the earliest cortical changes associated with AD in 71 cognitively healthy, adult children of AD patients (AD offspring) as compared with 69 with no family history of AD (non-AD offspring). Cortical thickness measures were obtained using FreeSurfer from 1.5T magnetic resonance (MR) scans. ApoE genotyping was obtained. Primary analyses examined family history and ApoeE4 effects on cortical thickness. Secondary analyses examined age effects within groups. All comparisons were adjusted using False Discovery …