Psychology Commons^™

Sertraline Effects On Cerebrospinal Fluid Monoamines And Species-Typical Socioemotional Behavior Of Female Cynomolgus Monkeys, Carol A. Shively, Thomas C. Register, James Dee Higley, Stephanie L. Willard

Faculty Publications

Rationale—Although widely prescribed, little is known about selective serotonin reuptake inhibitors (SSRIs) effects on social behavior and cerebrospinal fluid (CSF) monoamines in female primates.

Objective—To determine the effects of sertraline on agonistic and affiliative behavior.

Methods—21 adult female cynomolgus monkeys were housed in small, stable social groups, trained to participate in oral dosing, and began a 5-week cumulative dose response study. Serial doses of 0, 5, 10, 15, and 20 mg/kg of sertraline were administered orally for one week each. Behavior was recorded daily during 10-minute observations before and 4 hours after dosing. On the 7th day of dosing, circulating …