Psychology Commons^™

Activity In Both Hippocampus And Perirhinal Cortex Predicts The Memory Strength Of Subsequently Remembered Information, Y. Schrager, C. Brock Kirwan, L. R. Squire

Faculty Publications

An influential idea about memory and medial temporal lobe function suggests that hippocampal activity predicts subsequent recognition success only when decisions are based on recollection, whereas perirhinal activity predicts subsequent recognition success when decisions are based on familiarity. An alternative idea is that hippocampal and perirhinal activity are both sensitive to the level of overall memory strength. Using functional magnetic resonance imaging, we have tested the relationship between brain activity during learning and subsequent memory strength. Activity in a number of cortical regions (including regions within what has been termed the default network) was negatively correlated with subsequent memory strength, …