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Articles 1 - 30 of 55
Full-Text Articles in Psychology
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, Veronika Evangelina Espinoza
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, Veronika Evangelina Espinoza
Open Access Theses & Dissertations
The goal of our laboratory is to study the mechanisms that promote nicotine use, particularly in vulnerable populations such as adolescents and females. Thus, the purpose of this thesis was to characterize age and sex differences in the motivational/rewarding effects of nicotine (Aim 1) and withdrawal behavior (Aim 2). To more closely model human use patterns, the present study employed nicotine vapor methods involving passive exposure for 14 days in adolescent and adult female and male rats. Age and sex differences in approach behavior (nosepokes) were assessed in a port that delivered nicotine plumes on Day 1 and 14. Controls …
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Long-Term Effects Of Adolescent Fluoxetine Exposure On Hippocampal Gene Expression In Male C57bl/6 Mice, Anapaula Themann
Open Access Theses & Dissertations
Mood-related disorders, including depression and anxiety, are prevalent among children and adolescents. This poses a public health challenge, given their adverse impact on these young populations. Treatment with the selective serotonin reuptake inhibitor fluoxetine (FLX) is the first line of pharmacological intervention in pediatric patients suffering from affect-related illnesses. Although the use of this antidepressant has been deemed efficacious in the juvenile population, the enduring neurobiological consequences of adolescent FLX exposure are not well understood. For this reason, we explored for persistent molecular adaptations, in the adult hippocampus, as a function of adolescent FLX pretreatment. To do this, we administered …
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Open Access Theses & Dissertations
No abstract provided.
Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia
Ketamine Pre-Exposure Does Not Influence Later-Life Responses To Reward-Related Stimuli In Female C57bl/6 Mice, Israel Garcia
Open Access Theses & Dissertations
Preclinical work indicates that exposure to traditional antidepressant medications, in adolescent and adult female subjects, alters reward-related behavior later in life. In recent years, the anesthetic ketamine (KET), now used as a fast-acting antidepressant, has shown promising therapeutic efficacy for the management of depression. However, the potential long-term behavioral consequences of KET exposure across development have not been thoroughly assessed. Thus, to address this issue, we examined if KET exposure, during adolescence or early adulthood, results in enduring alterations in responsivity to the rewarding properties of sucrose and cocaine later in life. Specifically, female C57BL/6 mice were randomly assigned to …
The Language Content Of Computer-Mediated Versus Face-To-Face Motivational-Type Interviews, Karla Deyanira Llanes
The Language Content Of Computer-Mediated Versus Face-To-Face Motivational-Type Interviews, Karla Deyanira Llanes
Open Access Theses & Dissertations
Motivational Interviewing (MI) is an extensively used technique to facilitate behavior change by increasing a person's own motivation and commitment toward change. Recently, several innovative and effective ways to conduct motivational interviews have emerged. However, one potential option has not been investigated: the utility of conducting a motivational interview via computer. The current study begins to address this gap in knowledge by comparing the language content of computer-mediated motivational-type interviews and face-to-face motivational-type interviews. The motivational-type interviews were conducted with young adults who reported ambivalence about their level of recreational marijuana use. Specifically, non-marijuana users, occasional marijuana users, and frequent …
Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes, Bryan Cruz
Open Access Theses & Dissertations
This study examined whether the strong reinforcing effects of nicotine and changes in insulin biomarkers observed in diabetic rats are modulated via insulin. A model of diabetes was employed involving administration of streptozotocin (STZ), which produces hypoinsulinemia in rats. The present study included vehicle- or STZ-treated rats that received sham surgery or an insulin pellet. Two-weeks later, the rats were given extended access to intravenous self-administration (IVSA) of saline or nicotine. Concomitant changes in food intake, water responses, and body weight were assessed during 12 days of IVSA. After the last session, plasma levels of insulin, leptin, amylin, and glucagon-like …
Characterization Of Sex Differences In The Reinforcing Effects Of Nicotine, Rodolfo Jesus Flores Garcia
Characterization Of Sex Differences In The Reinforcing Effects Of Nicotine, Rodolfo Jesus Flores Garcia
Open Access Theses & Dissertations
It is presently unclear whether ovarian hormones, such as estradiol (E2) promote the reinforcing effects of nicotine in females. Thus, we compared extended access to nicotine intravenous self-administration (IVSA) in intact male, intact female, and OVX female rats (Study 1) as well as OVX females that received vehicle or E2 supplementation (Study 2). The E2 supplementation procedure involved a 4-day procedure involving 2 days of vehicle administration and 2 days of E2 administration. Two doses of E2 (25 or 250 ug) were assessed in separate groups of OVX females in order to examine the dose-dependent effects of this hormone on …
Differences In Stress Biomarkers In Women With High And Low Stress Appraisal, Clarissa Sara Gomez
Differences In Stress Biomarkers In Women With High And Low Stress Appraisal, Clarissa Sara Gomez
Open Access Theses & Dissertations
Measures of physiological biomarkers have been widely used in the field of stress research to explain how stress negatively impacts health outcomes. Women in particular have been shown to be more at risk for developing physiological and psychological stress-induced conditions (e.g., hypertension, depression) due to hormonal differences (Kirschbaum et al., 1992), but more importantly, because of their appraisal of stressful events (Schamus et al., 2008). Few studies however have examined whether womenâ??s stress appraisal is predictive of stress reactivity, as measured by stress biomarkers, during stressful events. The goal of this study was to examine whether stress appraisal predicted stress …
Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge
Open Access Theses & Dissertations
The following study investigated the extent to which time-dependent memory consolidation facilities the generalization of person-specific traits (individuated targets) to other, familiar social group members (familiar targets) Sixty-Nine (N = 69) participants learned to distinguish between two arbitrary groups, one positive and one negative. Participants learned the negative or positive information about a subset of the group members (individuated targets) and no individuating information about the familiar targets. Participants returned either without a time-delay containing sleep (2-6 hours after learning) or a time-delay with sleep (48 hours after learning). Results demonstrated that only after a time-delay containing sleep, negative information …
An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring
An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring
Open Access Theses & Dissertations
The evaluative oddball is an implicit measure for detecting (concealed) attitudes. In evaluative oddball studies, low occurrence stimuli such as negative pictures are presented among high occurrence context stimuli such as positive pictures. Late positive potentials (LPPs) of the event-related potential (ERP) are larger to evaluatively incongruent stimuli such as negatives compared to congruent stimuli such as positives with the context (e.g., positives). In prior evaluative oddball paradigms, this evaluative congruity effect of the LPP was reduced when participants concealed compared to truthfully reported attitudes. Because prior evaluative oddballs have been focused on the group level analysis, it has been …
Characterization Of The Behavioral, Biochemical And Molecular Indices Of Stress Produced By Nicotine Exposure And Withdrawal In Male And Female Rats, Oscar Valentin Torres
Characterization Of The Behavioral, Biochemical And Molecular Indices Of Stress Produced By Nicotine Exposure And Withdrawal In Male And Female Rats, Oscar Valentin Torres
Open Access Theses & Dissertations
Introduction: Tobacco use is a major economic and health problem. Particularly concerning is that women consume more tobacco products, have a more difficult time quitting, and are less likely to benefit from cessation therapies than men. As a result, women are at higher risk of developing tobacco-related diseases. Women are generally more susceptible to stress and are more likely to cope with stress by smoking as compared to men. During abstinence, women also experience intense anxiety as compared to men and report that the anxiety-reducing effects of smoking are the main reason for continued use and relapse. Thus, stress produced …
The Effects Of Extended Access To Methamphetamine Self-Administration On Dopaminergic Markers In The Striatum, Joe Luevano
The Effects Of Extended Access To Methamphetamine Self-Administration On Dopaminergic Markers In The Striatum, Joe Luevano
Open Access Theses & Dissertations
Methamphetamine (METH) abuse is a persistent problem in the U.S. and abroad. Escalation of METH use among independent users occurs for a variety of physiological and psychological reasons. Methamphetamine dependence may be attributed to the rewarding effect of this drug via the dopaminergic systems of the central nervous system (CNS). The presence of METH in the CNS increases synaptic release of dopamine. This increase in dopaminergic neurotransmission is thought to be directly attributed to the rewarding effects of METH. Following METH use, compensatory changes have been found to occur in the dopaminergic system during various periods of abstinence. It is …
Does Type Of Stimulus Influence Task-Irrelevant Evaluative Categorization Processes?, Guadalupe Corral
Does Type Of Stimulus Influence Task-Irrelevant Evaluative Categorization Processes?, Guadalupe Corral
Open Access Theses & Dissertations
The effect of stimulus type on task-irrelevant evaluative categorization was examined in two separate studies by using the P3 component from event-related brain potentials. The first study presented idiosyncratic stimuli consisting of individuals that were rated by participants as either positive or negative within sequences of pictorial and verbal stimuli. The second study presented sequences of novel and familiar stimuli consisting of previously normed unattractive and neutral individuals. It was hypothesized that pictures would elicit task-irrelevant evaluative categorization processes and so would novel stimuli (relative to words and familiar stimuli, respectively). Task-irrelevance was examined by assessing P3 peak amplitude to …
Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Open Access Theses & Dissertations
Previous studies have demonstrated that the behavioral effects of nicotine withdrawal are lower in adolescent versus adult rats. However, the neurochemical mechanisms that mediate these developmental differences are presently unclear. Much work has shown that nicotine reward is mediated via enhanced dopamine neurotransmission in the mesolimbic pathway which originates in the ventral tegmental area (VTA) and terminates in several forebrain structures including the nucleus accumbens (NAcc). More recently, studies have shown that nicotine withdrawal produces a decrease in NAcc dopamine transmission, an effect that is believed to serve as a neurochemical marker of withdrawal in adult rodents. The goal of …
Impact Of Serotonin 2c Receptor Null Mutation On Physiology And Behavior Associated With Nigrostriatal Dopamine Pathway Function., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Alcohol Self-Administration Acutely Stimulates The Hypothalamic-Pituitary-Adrenal (Hpa) Axis, But Alcohol Dependence Leads To A Dampened Neuroendocrine State, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Female Rats Display Dose-Dependent Differences To The Rewarding And Aversive Effects Of Nicotine In An Age-, Hormone-, And Sex-Dependent Manner., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Rodent Models Of Nicotine Reward: What Do They Tell Us About Tobacco Abuse In Humans?, Laura O'Dell
Rodent Models Of Nicotine Reward: What Do They Tell Us About Tobacco Abuse In Humans?, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Nicotine Withdrawal Produces Fewer Decreases In Extracellular Levels Of Dopamine In The Nucleus Accumbens Of Adolescent Versus Adult Rats., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
A Psychobiological Framework Of The Substrates That Mediate Nicotine Use During Adolescence, Laura O'Dell
A Psychobiological Framework Of The Substrates That Mediate Nicotine Use During Adolescence, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
A Study Of Possible Pre-Cognitive Advantages Of Bilingualism, Marisela Gutierrez
A Study Of Possible Pre-Cognitive Advantages Of Bilingualism, Marisela Gutierrez
Open Access Theses & Dissertations
Past research has suggested that second language acquisition has a beneficial effect on the development of inhibitory control processes in children and adults. This has been referred to as the "bilingual advantage" and is most commonly quantified using the Simon task. Whether the bilingual advantage extends to precognitive mechanisms has not yet been examined. The goals of this study were to examine the bilingual advantage in university students; and to examine whether the bilingual advantage extends to the precognitive filtering mechanism of sensorimotor gating. It was predicted that, as compared to monolinguals, bilingual university students would have greater inhibitory control, …
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Adolescent Nicotine Exposure Produces Less Affective Measures Of Withdrawal Relative To Adult Nicotine Exposure In Male Rats, Laura O'Dell
Adolescent Nicotine Exposure Produces Less Affective Measures Of Withdrawal Relative To Adult Nicotine Exposure In Male Rats, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
“Nicotine Deprivation Effect” In Rats With Intermittent 23-Hour Access To Intravenous Nicotine Self-Administration, Laura O'Dell
“Nicotine Deprivation Effect” In Rats With Intermittent 23-Hour Access To Intravenous Nicotine Self-Administration, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Diminished Nicotine Withdrawal In Adolescent Rats: Implications For Vulnerability To Addiction, Laura O'Dell
Diminished Nicotine Withdrawal In Adolescent Rats: Implications For Vulnerability To Addiction, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Viral Vector-Induced Amygdala Npy Overexpression Reverses Increased Alcohol Intake Caused By Repeated Deprivations In Wistar Rats, Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Crf–Crf1 System Activation Mediates Withdrawal-Induced Increases In Nicotine Self-Administration In Nicotine-Dependent Rats., Laura O'Dell
Crf–Crf1 System Activation Mediates Withdrawal-Induced Increases In Nicotine Self-Administration In Nicotine-Dependent Rats., Laura O'Dell
Laura Elena O'Dell
No abstract provided.
Behavioral And Neurochemical Responses To Cocaine In Periadolescent And Adult Rats, Laura O'Dell
Behavioral And Neurochemical Responses To Cocaine In Periadolescent And Adult Rats, Laura O'Dell
Laura Elena O'Dell
No abstract provided.