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Cognitive Behavioral Therapy Increases Amygdala Connectivity With The Cognitive Control Network In Both Mdd And Ptsd, Haochang Shou, Zhen Yang, Theodore Satterthwaite, Philip Cook, Steven Bruce, Russell Shinohara, Benjamin Rosenberg, Yvette Sheline
Cognitive Behavioral Therapy Increases Amygdala Connectivity With The Cognitive Control Network In Both Mdd And Ptsd, Haochang Shou, Zhen Yang, Theodore Satterthwaite, Philip Cook, Steven Bruce, Russell Shinohara, Benjamin Rosenberg, Yvette Sheline
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BackgroundBoth major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are characterized by alterations in intrinsic functional connectivity. Here we investigated changes in intrinsic functional connectivity across these disorders as a function of cognitive behavioral therapy (CBT), an effective treatment in both disorders.Methods53 unmedicated right-handed participants were included in a longitudinal study. Patients were diagnosed with PTSD (n = 18) and MDD (n = 17) with a structured diagnostic interview and treated with 12 sessions of manualized CBT over a 12-week period. Patients received an MRI scan (Siemens 3 T Trio) before and after treatment. Longitudinal functional principal components analysis …