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Full-Text Articles in Psychology
Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer
Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer
Theses and Dissertations
The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Rescuing Age-Related Proteolysis Deficits With Methylene Blue, Shane E. Pullins
Theses and Dissertations
The average lifespan is constantly increasing with the advent of new medical techniques, and age-related cognitive decline is becoming a prevalent societal issue. Even during healthy aging, humans and rats exhibit progressive deficits in episodic/declarative memory. In laboratory rats, age-related memory impairment can be assessed with trace fear conditioning (TFC). Recent research implicates ubiquitin proteasome system-mediated protein degradation in the synaptic plasticity supporting memory formation and retrieval. In rats, aging leads to decreased basal proteolytic activity in brain structures known to support the acquisition and retrieval of trace fear memories, and our preliminary data suggests activity-dependent proteasome activity declines in …
Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang
Is Contextual Cue Learning Flexible? An Eye-Movement Study Of The Contextual Cueing Task, Youcai Yang
Theses and Dissertations
Visual searching can be facilitated without awareness when the target is repeatedly presented in an invariant context in tasks such as contextual cueing (Chun & Jiang 1998). A behavioral cost (increased reaction time) was observed when the target was moved to a new location but no such cost was observed when the target returned to the initial location. The lack of cost for return suggests two possible explanations: One is that the learning can update the initial learning to acquire both target locations, which suggests the implicit learning is flexible. The other is that the contextual cue leaning cannot update …