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Neuroscience and Neurobiology

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Full-Text Articles in Psychology

Similarities Between Human And Animal Spatial Memory: Item And Order Information, Robert H.I. Dale Jun 2014

Similarities Between Human And Animal Spatial Memory: Item And Order Information, Robert H.I. Dale

Robert H. I. Dale

Human subjects, sitting at the center of a circle of eight lights, were tested on analogues of radial-maze item-recognition (Roberts & Smythe, 1979) and order-recognition (Kesner & Novak, 1982) tasks. Subjects in the item-recognition condition saw a list of seven lights, and then the nonlist (eighth) light was tested against the first, fourth, or seventh light from the list. The sub- jects were required to point toward the non list light. Subjects in the order-recognition condition saw a series of eight lights, followed by a test of the first and second, fourth and fifth, or seventh and eighth serial positions. …


Spatial And Temporal Response Patterns On The Eight-Arm Radial Maze, Robert H.I. Dale Jun 2014

Spatial And Temporal Response Patterns On The Eight-Arm Radial Maze, Robert H.I. Dale

Robert H. I. Dale

Six maze-experienced hooded rats were timed during five trials on which they collected water from all arms of an eight-arm radial maze, then made five more choices. All subjects frequently exhibited a “task-completion pause:” The subjects rarely spent more than 1 sec in the center of the maze between choices until they had entered all eight arms, then stopped in the center of the maze. In contrast, the time spent in each arm gradually increased until all of the water had been obtained, then decreased slightly. Four subjects began every trial by choosing eight consecutive adjacent arms. The task-completion pause …


The Relative Attenuation Of Self-Stimulation, Eating And Drinking Produced By Dopamine-Receptor Blockade, E. T. Rolls, B. J. Rolls, P. H. Kelly, S. G. Shaw, R. J. Wood, Robert H.I. Dale Jun 2014

The Relative Attenuation Of Self-Stimulation, Eating And Drinking Produced By Dopamine-Receptor Blockade, E. T. Rolls, B. J. Rolls, P. H. Kelly, S. G. Shaw, R. J. Wood, Robert H.I. Dale

Robert H. I. Dale

Spiroperidol, which blocks dopamine (DA) receptors, attenuated self-stimulation of the nucleus accumbens, septal area, hippocampus, anterior hypothalamus and ventral tegmental area. Dopamine is thus involved in self-stimulation of many sites (in addition to the lateral hypothalamus). The attenuation was not a simple motor impairment of the speed of bar-pressing in that the nucleus accumbens and septal self-stimulation rates were lower than those in treated animals self-stimulating at other sites (Experiment 1). Feeding was partly attenuated, and drinking was much less attenuated by the spiroperidol. Since the rats bar-pressed for brain- stimulation reward, chewed pellets to eat, and licked a tube …


Limitations On Spatial Memory In Mice, Robert H.I. Dale, Martin Bedard May 2014

Limitations On Spatial Memory In Mice, Robert H.I. Dale, Martin Bedard

Robert H. I. Dale

Rats have an impressive ability to remember locations they have visited. Two experiments used an eight-arm radial maze to determine whether mice showed two important characteristics of this spatial memory: its durability, and its dependence on stimuli outside the maze (extreme stimuli). In Experiment 1, food-deprived mice were allowed to eat from four of the eight arms of the maze then, after delays of 5 sec, 1 min, or 5 min, they were permitted to choose the remaining arms. Choice accuracy declined significantly with the longer delays, but always remained above chance. In Experiment 2, the maze was rotated 180° …