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Full-Text Articles in Psychology
Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau
Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau
Theses and Dissertations
ABSTRACT
NEURAL PLASTICITY OF EXTINCTION LEARNING: RELATIONS WITH ANXIETY AND EXTINCTION RETENTION
by
Emily L. Belleau
The University of Wisconsin-Milwaukee, 2016
Under the Supervision of Associate Professor Christine Larson
Anxiety is a significant public health problem characterized by substantial psychological, physical, and economic burden. A key feature of anxiety is the inability to regulate fear. Aberrant extinction of conditioned fear is one prominent model of the etiology of anxiety disorders. Previous studies have shown that the neural circuitry underlying anxiety pathology overlaps with that mediating fear extinction learning. Recently, more precise pathways supporting the expression (CMA-aMCC) and inhibition (BLA-vmPFC) of …
Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis
Regulation Of Mtor And Erk Signaling In The Amygdala Through Proteolytic Modulation Of Pp2a Activity Following Auditory Fear Learning, David Sylvan Reis
Theses and Dissertations
The consolidation of fear memories is known to depend on a number of critical cellular processes including de novo protein synthesis and 26S proteasome-dependent protein degradation following auditory fear conditioning (Jarome et al., 2011; Kwapis et al., 2011). Early work has suggested that protein degradation, mediated by the ubiquitin proteasome system (UPS), may regulate the requirement for de novo protein synthesis during memory consolidation (Jarome & Helmstetter, 2014). However, the precise way in which the UPS is able to regulate mechanisms of protein synthesis remain unclear. In the present set of experiments, we investigated the role of the protein phosphatase …