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Full-Text Articles in Psychology
The Effects Of Exercise Pattern And Intensity On The Expression Of Flk-1 And Flt-1 Receptors In The Hippocampus And Cerebellum, Morgan E. Stevenson
The Effects Of Exercise Pattern And Intensity On The Expression Of Flk-1 And Flt-1 Receptors In The Hippocampus And Cerebellum, Morgan E. Stevenson
Theses and Dissertations
Aerobic exercise benefits the body and brain. In the brain, these benefits include neuroprotection and improved cognition. These exercise-induced changes are attributed in part to angiogenesis: the growth of new capillaries from preexisting vessels. One critical factor involved in the regulation of angiogenesis is VEGF and its receptors Flk-1 and Flt-1. Although exercise is generally found to be beneficial, there are wide variations in the exercise regimens used across experiments. This study standardized some of these variations. In this study, rats were either assigned to a voluntary wheel running or a forced wheel running exercise condition. Within each condition, animals …
Exercise-Induced Hypoxia, Angiogenesis, And Behavioral Flexibility In The Adult Rat, Kiersten Lee Berggren
Exercise-Induced Hypoxia, Angiogenesis, And Behavioral Flexibility In The Adult Rat, Kiersten Lee Berggren
Theses and Dissertations
Exercise induces a myriad of effects on the brain from the growth of new capillaries and neurons, to improvements in cognitive performance. Additionally, recent research has shown that commencement of an exercise regimen also causes apoptosis. Therefore, it is possible that exercise-induced increases in oxygen demand cause the brain to transiently experience a state of hypoxia. To investigate this hypothesis, we measured protein levels of hypoxia inducible factor 1 alpha (HIF-1α), a transcription factor known to be upregulated in conditions of hypoxia or ischemia, in animals exposed to a single bout of treadmill exercise. After exercise animals were sacrificed at …