Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Psychology
Identification Of A Core Amino Acid Motif Within The Α Subunit Of Gabaars That Promotes Inhibitory Synaptogenesis And Resilience To Seizures, Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Identification Of A Core Amino Acid Motif Within The Α Subunit Of Gabaars That Promotes Inhibitory Synaptogenesis And Resilience To Seizures, Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Psychology Faculty Research
The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and neurons can target these subtypes to specific synapses. Here, we identify a 15-amino acid inhibitory synapse targeting motif (ISTM) within the α2 subunit that promotes the association between GABAARs and the inhibitory scaffold proteins collybistin and gephyrin. Using mice in which the ISTM has been introduced into the α1 subunit (Gabra1-2 mice), we show that the ISTM is critical for axo-axonic synapse formation, the efficacy of GABAergic …
Social Context-Dependent Activity In Marmoset Frontal Cortex Populations During Natural Conversations, Samuel U. Nummela, Vladimir Jovanovic, Lisa De La Mothe, Cory T. Miller
Social Context-Dependent Activity In Marmoset Frontal Cortex Populations During Natural Conversations, Samuel U. Nummela, Vladimir Jovanovic, Lisa De La Mothe, Cory T. Miller
Psychology Faculty Research
Communication is an inherently interactive process that weaves together the fabric of both human and nonhuman primate societies. To investigate the properties of the primate brain during active social signaling, we recorded the responses of frontal cortex neurons as freely moving marmosets engaged in conversational exchanges with a visually occluded virtual marmoset. We found that small changes in firing rate (∼1 Hz) occurred across a broadly distributed population of frontal cortex neurons when marmosets heard a conspecific vocalization, and that these changes corresponded to subjects' likelihood of producing or withholding a vocal reply. Although the contributions of individual neurons were …
Responses Of Primate Frontal Cortex Neurons During Natural Vocal Communication, Cory T. Miller, A. Wren Thomas, Samuel U. Nummela, Lisa A. De La Mothe
Responses Of Primate Frontal Cortex Neurons During Natural Vocal Communication, Cory T. Miller, A. Wren Thomas, Samuel U. Nummela, Lisa A. De La Mothe
Psychology Faculty Research
The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization processing occurs in ventrolateral prefrontal cortex neurons, vocal-motor activity has been conjectured to be primarily subcortical and suggestive of a distinctly different neural architecture from humans. Direct evidence of neural activity during natural vocal communication is limited, as previous studies were performed in chair-restrained animals. Here we recorded the activity of single neurons across multiple regions of prefrontal and premotor cortex while freely moving marmosets engaged in a natural vocal behavior known as antiphonal calling. Our …
Feedforward And Feedback Projections Of Caudal Belt And Parabelt Areas Of Auditory Cortex: Refining The Hierarchical Model, Troy A. Hackett, Lisa A. De La Mothe, Corrie R. Camalier, Arnaud Falchier, Peter Lakatos, Yoshinao Kajikawa, Charles E. Schroeder
Feedforward And Feedback Projections Of Caudal Belt And Parabelt Areas Of Auditory Cortex: Refining The Hierarchical Model, Troy A. Hackett, Lisa A. De La Mothe, Corrie R. Camalier, Arnaud Falchier, Peter Lakatos, Yoshinao Kajikawa, Charles E. Schroeder
Psychology Faculty Research
Our working model of the primate auditory cortex recognizes three major regions (core, belt, parabelt), subdivided into thirteen areas. The connections between areas are topographically ordered in a manner consistent with information flow along two major anatomical axes: core-belt-parabelt and caudal-rostral. Remarkably, most of the connections supporting this model were revealed using retrograde tracing techniques. Little is known about laminar circuitry, as anterograde tracing of axon terminations has rarely been used. The purpose of the present study was to examine the laminar projections of three areas of auditory cortex, pursuant to analysis of all areas. The selected areas were: middle …