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Ventromedial Prefrontal Cortex Damage Is Associated With Decreased Ventral Striatum Volume And Response To Reward, Maia S. Pujara, Carissa L. Philippi, Julian C. Motzkin, Mustafa K. Baskaya, Michael Koenigs
Ventromedial Prefrontal Cortex Damage Is Associated With Decreased Ventral Striatum Volume And Response To Reward, Maia S. Pujara, Carissa L. Philippi, Julian C. Motzkin, Mustafa K. Baskaya, Michael Koenigs
Carissa Philippi
The ventral striatum and ventromedial prefrontal cortex (vmPFC) are two central nodes of the “reward circuit” of the brain. Human neuroimaging studies have demonstrated coincident activation and functional connectivity between these brain regions, and animal studies have demonstrated that the vmPFC modulates ventral striatum activity. However, there have been no comparable data in humans to address whether the vmPFC may be critical for the reward-related response properties of the ventral striatum. In this study, we used fMRI in five neurosurgical patients with focal vmPFC lesions to test the hypothesis that the vmPFC is necessary for enhancing ventral striatum responses to …