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Neural Underpinnings Of Working Memory In Adult Survivors Of Childhood Brain Tumors, Tricia Z. King, Sabrina Na, Hui Mao
Neural Underpinnings Of Working Memory In Adult Survivors Of Childhood Brain Tumors, Tricia Z. King, Sabrina Na, Hui Mao
Psychology Faculty Publications
Objective: Adult survivors of childhood brain tumors are at risk for cognitive performance deficits that require the core cognitive skill of working memory. Our goal was to examine the neural mechanisms underlying working memory performance in survivors. Method: We studied the working memory of adult survivors of pediatric posterior fossa brain tumors using a letter n-back paradigm with varying cognitive workload (0-, 1-, 2-, and 3-back) and functional magnetic resonance imaging as well as neuropsychological measures. Results: Survivors of childhood brain tumors evidenced lower working memory performance than demographically-matched healthy controls. Whole-brain analyses revealed significantly greater blood-oxygen level dependent (BOLD) …