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The Effects Of Dextromethorphan On Response Acquisition With Delayed Reinforcement, Thomas B. Morgan

Dissertations

The current study examined in 2-h sessions the effects of intraperitoneal injections of dextromethorphan (DM) (0.0, 40.0, 60.0, and 80.0 mg/kg) on the acquisition of lever-press responding in rats that were exposed to a two-lever procedure in which responses on the reinforcement lever (RL) were reinforced with food after a 15-s resetting delay and responses on the cancellation lever cancelled a scheduled reinforcer. Response acquisition was observed at all drug doses. A decrease in RL responses, food deliveries, and the number of subjects that acquired responding was observed at the highest dose of DM. All doses of DM increased latency …