Psychology Commons^™

Sequential Super-Stereotypy Of An Instinctive Fixed Action Pattern In Hyper-Dopaminergic Mutant Mice: A Model Of Obsessive Compulsive Disorder And Tourette's, Kent C. Berridge, J Wayne Aldridge, Kimberly R. Houchard, Xiaoxi Zhuang

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Excessive sequential stereotypy of behavioral patterns (sequential super-stereotypy) in Tourette's syndrome and obsessive compulsive disorder (OCD) is thought to involve dysfunction in nigrostriatal dopamine systems. In sequential super-stereotypy, patients become trapped in overly rigid sequential patterns of action, language, or thought. Some instinctive behavioral patterns of animals, such as the syntactic grooming chain pattern of rodents, have sufficiently complex and stereotyped serial structure to detect potential production of overly-rigid sequential patterns. A syntactic grooming chain is a fixed action pattern that serially links up to 25 grooming movements into 4 predictable phases that follow 1 syntactic rule. New …