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Full-Text Articles in Psychology
Polygenic Hazard Scores In Preclinical Alzheimer's Disease, Chin Hong Tan, Bradley T. Hyman, Jacinth J. X. Tan, Christopher P. Hess, William P. Dillon, Gerard D. Schellenberg, Lilah M. Besser, Walter A. Kukull, Karolina Kauppi, Linda K. Mcevoy, Ole A. Andreassen, Anders M. Dale, Chun Chieh Fan, Rahul S. Desikan
Polygenic Hazard Scores In Preclinical Alzheimer's Disease, Chin Hong Tan, Bradley T. Hyman, Jacinth J. X. Tan, Christopher P. Hess, William P. Dillon, Gerard D. Schellenberg, Lilah M. Besser, Walter A. Kukull, Karolina Kauppi, Linda K. Mcevoy, Ole A. Andreassen, Anders M. Dale, Chun Chieh Fan, Rahul S. Desikan
Research Collection School of Social Sciences
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration.
Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi
Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi
Research Collection School of Social Sciences
This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound …