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Psychology Commons

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Medicine and Health Sciences

Western Michigan University

Depression

Publication Year

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Full-Text Articles in Psychology

Preclinical Behavioral Assessment Of Chronic, Intermittent Low-Dose Psilocybin In Rodent Models Of Depression And Anxiety, Harmony I. Risca Aug 2021

Preclinical Behavioral Assessment Of Chronic, Intermittent Low-Dose Psilocybin In Rodent Models Of Depression And Anxiety, Harmony I. Risca

Dissertations

Recent studies have demonstrated the clinical efficacy of psychedelic-assisted psychotherapy for treatment-resistant depression and anxiety. Amidst the overall success of recent clinical trials using a single high dose of psilocybin, anecdotal reports indicate anxiolytic and antidepressant effects following a repeated low dose regimen. As therapeutic outcomes are often tightly intertwined with the individual’s subjective experience, animal models are used as objective measures to investigate the underlying mechanisms responsible for the putative antidepressant/anxiolytic effects of psychedelics. Three rodent models predictive of anxiolytic or antidepressant effects were used to evaluate effects of chronic intermittent low dose (CILD) psilocybin treatment; the Light/Dark conflict …


Testing A Model Of Maladaptive Perfectionism And Depression Symptoms: The Roles Of Emotional Disclosure, Emotion Regulation Strategies, Adult Attachment, And Shame, Angela M. Garrison Jun 2014

Testing A Model Of Maladaptive Perfectionism And Depression Symptoms: The Roles Of Emotional Disclosure, Emotion Regulation Strategies, Adult Attachment, And Shame, Angela M. Garrison

Dissertations

Previous research has supported a link between maladaptive perfectionism and higher levels of depression symptoms. However, researchers have not yet investigated the ways in which emotion regulation processes may mediate this relationship. Therefore, the primary purpose of this study was to evaluate emotional disclosure, emotional avoidance, and rumination as mediators of the relation between maladaptive perfectionism and depression symptoms. Additionally, this study also investigated the role that insecure attachment orientations play in the relationship between maladaptive perfectionism and use of particular emotion regulation strategies. Further, the role of shame in the emotion regulation processes of individuals with higher levels of …


An Evaluation Of Social Capital's Effect On Depression Among Adolescents, Ezechukwu Awgu Dec 2012

An Evaluation Of Social Capital's Effect On Depression Among Adolescents, Ezechukwu Awgu

Dissertations

Mental illness has been described as a “global burden of disease,” and depression accounts for a large part of the burden (Aslund, Starrin, Nilsson, 2010). In 2009, 35.7 percent of the adolescent population in the United States who reported past-year symptoms of a major depressive episode, for example, feelings of sadness, discouragement, loss of feelings of self-worth, and loss of interest in social activities, also used illicit drugs including marijuana, inhalants, hallucinogens, cocaine, heroin, and prescription-type psychotherapeutics for non-medical purposes (SAMHSA, 2009, APA, 1994). Additionally, substance abuse due to alcoholism was among the major causes of death for adolescents aged …