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Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Dissertations (1934 -)
Cognitive reserve (CR) indexes the nonlinear relationship between neurological insult and behavioral change. CR is manifested in both static factors (e.g., childhood environment, education) and modifiable lifestyle factors, (e.g., leisure activities). Detailed investigation of the influence of CR on cortical thickness, which indexes neuropathology, and cognitive functioning could be particularly important in understanding the heterogeneity of Alzheimer’s disease (AD). While memory decline is the hallmark of AD, executive functioning (EF) decline often predates memory changes, making EF an important target for investigating CR influences. The current study examines the relationship of CR and genetic risk for AD (ε4) on EF …