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Full-Text Articles in Psychology
Immunolesions Using Site Specific Injections Of 192-Lgg Saporin Into The Basal Forebrain Fail To Affect Radial Arm Maze Performance In The Male Rat, Lesley J. Hickman '96
Immunolesions Using Site Specific Injections Of 192-Lgg Saporin Into The Basal Forebrain Fail To Affect Radial Arm Maze Performance In The Male Rat, Lesley J. Hickman '96
Honors Projects
In this study I investigated the effects of 192-lgG saporin injections into the medial septal area.(MSA) and nucleus basalis magnocel/ularis (NBM) on radial arm maze performance in the male rat. The results of the present study reveal that combined injections of 192-lgG saporin into the basal forebrain failed to disrupt RAM performance when compared to vehicle-injected controls. In addition, intraperitoneal injections using a muscarinic receptor blocker, scopolamine, failed to reveal a compensatory response of the cholinergic basal forebrain that may have explained the lack of behavioral effects of 192IgG saporin. Consequently, the results of this study suggest that a selective …
Comparison Of The Effects Of Saporin-Igg Injections Into The Nucleus Basalis Magnocellularis And Medial Septal Area Of Male Rat As Assessed By The Morris Water Maze Task, Alexander R. V. Mccampbell '95
Comparison Of The Effects Of Saporin-Igg Injections Into The Nucleus Basalis Magnocellularis And Medial Septal Area Of Male Rat As Assessed By The Morris Water Maze Task, Alexander R. V. Mccampbell '95
Honors Projects
Alzheimer's disease currently afflicts approximately 4 million people in the United States, with 100,000 new cases being reported each year. As post mortem examination of AD patientsI brains has revealed a significant decrease in the number of cholinergic neurons, one approach we have taken is to look at the correlation between the depletion of certain cholinergic markers in animals and the resulting behavioral deficits. Two regions of specific interest are the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM). These regions are important because they are the major source of cholinergic neurons in the brain, they are selectively …
Toward An Understanding Of Alzheimer's Disease: The Effects Of B-Amyloid(1-42) And Ibotenic Acid On The Retention Of A Spatial Learning Task In Rats F:Ollowing Multiple Injections Into The Hippocampus, Jason Pequette '94
Honors Projects
Neuropathologically, Alzheimer's disease (AD) is characterized by neuritic plaques and neurofibrillary tangles. Evidence has suggested that a protein called B-amyloid (BA) is a major component of the neuritic plaques and may playa role in the neurodegeneration seen in AD. The cellular mechanisms by which BA induces neurotoxicity, however, are still unclear. Recent evidence suggests that the aggregational state of BA may be relevant to its neurotoxicity. Whether portions of the BA protein or the entire sequence produces neurotoxicity in neurons, however, remains a controversy. Still another controversy is whether BA is directly neurotoxic to neurons or whether it increases the …
The Effects Of Bilateral Injections Of Neuropeptide K Into The Medial Preoptic Area On Male Rat Copulatory Behavior, Peter Malen '91
The Effects Of Bilateral Injections Of Neuropeptide K Into The Medial Preoptic Area On Male Rat Copulatory Behavior, Peter Malen '91
Honors Projects
The first mammalian neuropeptide to be characterized was substance P (sP) , and it is now recognized that sP is a member of a structurally related family of peptides, the tachykinins. Extensive studies have demonstrated. that sP and some related tachykinin peptides play key roles as neurotransmitters and neuromodulators. The synthesis of different members of the tachykinin family is in part due to the modifications' of three sP-encoding preprotachykinin (PPT) mRNA's that are derived from a single sP gene. At least four tachykinin peptides can be synthesized as a result of these differential modifications including sP, neurokinin A, neuropeptide and …
Intracerebral Injections Of Substance P Fragments (5-11) And (1-7) Into The Dorsal Midbrain Central Gray Have No Effects On Lordosis Behavior In The Female Rat, Jodi K. Block '91
Intracerebral Injections Of Substance P Fragments (5-11) And (1-7) Into The Dorsal Midbrain Central Gray Have No Effects On Lordosis Behavior In The Female Rat, Jodi K. Block '91
Honors Projects
Substance P (sP), a neuroactive peptide, has now been implicated in a wide range of behaviors. One in particular is female rat sexual behavior. Recently, it has been shown that bilateral injections of sP into the dorsal midbrain central gray (dMCG) of estrogen-primed female rats facilitate sexual behavior (lordosis). Uncertainty remains, however, concerning the mode of action of synaptically released sP. Indeed, most of our understanding of sP activity has revealed that its full structural sequence is not needed for biological activity. This has led to speculation that sP may be processed into one or more types of fragments before …