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Characterization Of Ethanol-Related Phenotypic Differences Between C57bl/6j And C57bl/6nj Substrains: Role Of Cyfip2?, Matthew C. Hartmann
Characterization Of Ethanol-Related Phenotypic Differences Between C57bl/6j And C57bl/6nj Substrains: Role Of Cyfip2?, Matthew C. Hartmann
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The C57BL/6 (B6) mouse is the most commonly used inbred strain in biomedical research, and has served as the basis for various large-scale genetic and genomic projects. Although the parental substrain, C57BL/6J (B6J), originated at The Jackson Laboratory, isolated breeding colonies are now maintained at numerous sites. This separation has resulted in genetic drift that has led to the emergence of phenotypic differences among these colonies. For instance, B6J mice display higher levels of voluntary ethanol consumption and increased locomotor responses to psychostimulants, relative to C57BL/6N mice (B6N). Initial progress has been made in elucidating the genetic bases of these …