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Full-Text Articles in Psychology
Hpa Axis Genetic Variation And Life Stress Influences On Functional Connectivity In Resting State Networks, Tara Ann Miskovich
Hpa Axis Genetic Variation And Life Stress Influences On Functional Connectivity In Resting State Networks, Tara Ann Miskovich
Theses and Dissertations
Stressful or traumatic experiences are a key risk factor for developing psychopathology, primarily through the impact that chronic stress has on hypothalamic-pituitary-adrenal (HPA) axis functioning. The HPA axis regulates the stress response but can become dysregulated with chronic activation and impact brain functioning. In addition to environmental stressors, genetic variation in genes in the HPA axis appear to influence HPA axis functioning and is also related to disruption in brain functioning, particularly in the context of high life stress. The current study focused on examining potential mechanisms through which trauma and stress interacts with HPA axis genes to impact key …
Alcohol Use Disorders And An Fmri Stress Task: A Connectivity Analysis, Natasha E. Wright
Alcohol Use Disorders And An Fmri Stress Task: A Connectivity Analysis, Natasha E. Wright
Theses and Dissertations
Little research has been conducted on neuronal stress processing in individuals
with alcohol dependence (AD). The present study examined neural stress response in AD individuals compared to controls using an fMRI stress task, assessing amygdala
activation and its connectivity to the medial prefrontal cortex (mPFC). Further, the study
analyzed the impact of hormone levels and subjective stress on frontal-limbic
connectivity patterns.
Ten abstinent AD individuals and 11 controls were recruited. Subjects
participated in an fMRI stress task. A region of interest (amygdala) analysis was
conducted using area-under-the-curve. This activation was then examined in a whole brain functional connectivity analysis. Follow-up …