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Characterization Of A Novel, Stress-Responsive Sexually Dimorphic Corticotropin-Releasing Factor Receptor 1 (Crfr1) Nucleus In The Rostral Anteroventral Periventricular Nucleus Of The Mouse, Zachary Julius Rosinger
Characterization Of A Novel, Stress-Responsive Sexually Dimorphic Corticotropin-Releasing Factor Receptor 1 (Crfr1) Nucleus In The Rostral Anteroventral Periventricular Nucleus Of The Mouse, Zachary Julius Rosinger
Legacy Theses & Dissertations (2009 - 2024)
Within the United States, women are at double the risk of men to develop a stress-related mood disorder (e.g., anxiety or depression) during their reproductive years (Kornstein et al., 2000; Kessler et al., 2005). Many factors contribute to the potential sex difference in such disorders, including gonadal hormones (hypothalamic-pituitary-gonadal axis; HPG) and how they interact with the stress response system, or hypothalamic-pituitary-adrenal (HPA) axis. Corticotropin-releasing factor (CRF) signals through binding the GS-coupled receptor, CRF receptor 1 (CRFR1), and activity between CRF/CRFR1 regulates the hormonal and behavioral stress response (Chen et al., 1993; Bale and Vale, 2004; Heinrichs et al., 1995; …