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Bred rats; acoustic startle; methylphenidate effects; food deprivation; startle reflex; intra-individual differences; inter-individual differences; prepulse inhibition
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Modulation Of Methylphenidate Effects On Wheel Running And Acoustic Startle By Acute Food Deprivation In Commercially And Selectively Bred Rats., Clinton Chapman, Nancy Dess, Ian Mclaughlin
Modulation Of Methylphenidate Effects On Wheel Running And Acoustic Startle By Acute Food Deprivation In Commercially And Selectively Bred Rats., Clinton Chapman, Nancy Dess, Ian Mclaughlin
Clinton D Chapman
Behavioral effects of the same dose of the same drug can vary in degree and direction between and within individuals. The present study examines behavioral base rates, feeding status, and dispositional differences as sources of inter- and intra-individual heterogeneity in drug response. Modulation of the effects of methylphenidate (MPD) on wheel running and acoustic startle by food deprivation was examined in three experiments. Freely fed or food deprived Harlan Sprague–Dawley rats (running study) or rats selectively bred for low (LoS) and high (HiS) saccharin intake (running and startle studies) were given MPD (10 mg/kg) or saline before testing. Overall drug …