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Neuropsychological Implications Of Nocturnal Hypoxemia In Sickle Cell Disease, Sheena Ram

Theses and Dissertations

Neuropsychological impairments have been observed in both individuals with sleep-disordered breathing and in individuals with sickle cell disease (SCD), but there has been little research on the potential effect of sleep-disordered breathing on neuropsychological function in individuals with SCD. This study aims to examine the effect nocturnal oxygen desaturations have on neuropsychological functioning in individuals with sickle cell disease when compared to those with non-sickle anemia and healthy controls. Thirty-four participants with SCD, 18 non-sickle anemia controls (ACTL), and 29 healthy controls (CTL), ages 9 to 63 years, participating in an IRB-approved Children’s Hospital Los Angeles study of cerebral blood …