Psychology Commons^™

Effects Of A Psychological Stressor On Methamphetamine Seeking In Rats., Kayla B. Cox

Psychology ETDs

Although methamphetamine abuse and fatality rates are on the rise in the United States, there are currently no FDA approved drugs to treat methamphetamine use disorder (MUD). To better understand factors contributing to addiction, researchers have designed various rodent models of stress including the use of footshock, social defeat and maternal separation, however, these models involve physical or early life stress exposure and thus are less translatable to human psychological stress. The present study implemented predatory odors as a model of psychological stress and examined whether chronic exposure to these stressors enhanced subsequent vulnerability to a subthreshold dose of methamphetamine. …