Psychology Commons^™

Mdma And Learning: Effects Of Acute And Neurotoxic Exposure, Thomas P. Byrne

Dissertations

In two experiments, the effects of MDMA were examined on the acquisition of lever-press responding by rats exposed to procedures in which water delivery was delayed by 0, 10, or 20 seconds. In the first experiment, naive, water-deprived rats received an intraperitoneal injection of MDMA (0, 1.0, 3.2, or 5.6 mg/kg) prior to one experimental session. Response acquisition was observed under all conditions at all drug doses. MDMA increased both response rates and reinforcers earned in a dose-dependent fashion, but only when reinforcement was immediate. Under conditions of delay, MDMA had no effect on the number of lever presses emitted …

A Computer/Tutorial System Compared With A Workbook/Tutorial Systeg For Presenting Instructional Material To At-Risk Elementary School Students, Vincent O. Hodge

Dissertations

Two different ways of presenting instructional material and reacting to students’ responses were compared. One, taking advantage of several features of multimedia instruction involved a desktop computer and various computer-presented consequences of correct and incorrect responses (largely chosen by the student). The other consisted in presenting the same instructional materials (the SRA primary curriculum) in a workbook form with tutors' comments and praise as the main form of response consequence. The two methods were compared with respect to various measures of student and system performance, including student accuracy (percent correct responses), types of errors, amount of correct response repetition (over-responding), …

Disruption Of The Discriminative Stimulus Effects Of (+)-3, 4-Methylenedioxymethamphetamine (Mdma) By (± )-Mdma Neurotoxicity: Protection By Fluoxetine, Thomas B. Virden Iii

Dissertations

It is well established that repeated, high doses of 3, 4-methylenedioxymethamphetamine (MDMA) result in the long-term depletion of serotonin levels and destruction of serotonergic terminals in various locations in the brains of a variety of species. Further, it is also well known that concomitant injections of the serotonin reuptake inhibitor, fluoxetine, prevents this deterioration. It has recently been noted that such MDMA neurotoxicity disrupts stimulus control in rats trained to discriminate MDMA from saline in a drug discrimination procedure (Schechter, 1991a).

In order to extend Schechter's findings to the optical isomers of MDMA and to explore the potential of fluoxetine …