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Full-Text Articles in Psychology
Chlordiazepoxide Increases Risky Choice, Devin Andrew Galdieri
Chlordiazepoxide Increases Risky Choice, Devin Andrew Galdieri
Graduate Theses, Dissertations, and Problem Reports
Probability discounting is a measure of risky choice that is correlated with maladaptive behavior and psychological disorders. Benzodiazepines are a class of drug on which relatively little risky-choice research has been conducted, particularly under conditions of chronic drug exposure. Chlordiazepoxide, a standard benzodiazepine, was administered to rats that had been trained to respond on a risky-choice task in which a choice was available between a single food pellet with 100% certainty or three food pellets with probabilities of delivery that decreased across each experimental session. During baseline, responding was sensitive to the programmed contingencies and larger-reinforcer choice decreased as the …
Delay Discounting And Cannabinoid Enzyme Inhibitors, Devin Andrew Galdieri
Delay Discounting And Cannabinoid Enzyme Inhibitors, Devin Andrew Galdieri
Graduate Theses, Dissertations, and Problem Reports
Delay discounting is a measure of impulsive choice that is correlated with maladaptive behavior and psychological disorders. Disruptions to serotonin and dopamine pathways can cause changes in delay discounting, as can lesions to the prefrontal cortex and nucleus accumbens. The endocannabinoid system modulates other neurotransmitter systems, including dopamine and serotonin pathways. Cannabinoid receptors type 1 are found in relatively high concentrations in the nucleus accumbens and the prefrontal cortex. These receptors are activated by endogenous cannabinoids, which are synthesized on demand and broken down by catabolic enzymes. The action of these enzymes can be inhibited by a class of drugs …