Psychology Commons^™

Exercise As A Therapeutic For Hiv-1-Associated Neurocognitive Deficits, Michael N. Cranston

Theses and Dissertations

Human Immunodeficiency Virus (HIV-1) afflicts nearly 38 million individuals worldwide (Joseph et al., 2013; “WHO | HIV/AIDS,” 2016). Despite the reduction in disease mortality due to increased use of antiretroviral medication, HIV-1 associated neurocognitive disorder (HAND) affects approximately 50% of HIV infected individuals (Antinori et al., 2007; Castellon, Hinkin, Wood, & Yarema, 1998; Castelo, Sherman, Courtney, Melrose, & Stern, 2006; Cysique & Brew, 2009; Heaton et al., 2011, 2015). The brain itself is particularly sensitive to HIV-1 related viral proteins and viral infection (Masliah, DeTeresa, Mallory, & Hansen, 2000), thus, it is vital to empirically examine potentially effective therapeutics which …