Psychology Commons^™

An Investigation Of Short-Term Memory Functioning In A Neurodevelopmental Rat Model Of Schizophrenia, Ashley M. Moyett

Seton Hall University Dissertations and Theses (ETDs)

Schizophrenia is a debilitating disorder characterized by positive, negative, and cognitive symptoms. Cognitive deficits affect one’s learning and memory due to a dysfunction in the brain, inhibiting a normal functioning life. The self-medicating hypothesis states that ninety percent of people with schizophrenia smoke, because nicotine use improves these cognitive deficits. The cytokine hypothesis states that inflammation due to prenatal infection is associated with schizophrenia. These increased proinflamatory cytokines can damage the brains of the fetuses, which can cause schizophrenic-like symptoms in rats. The present study used Lipopolysaccharides to activate the cytokine-mediated inflammatory response injected into pregnant dams. A T-maze was …