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Full-Text Articles in Psychology
Multivariate Genome-Wide Association Study Of Rapid Automatised Naming And Rapid Alternating Stimulus In Hispanic American And African–American Youth, Dongnhu Thuy Truong, Andrew Kenneth Adams, Steven Paniagua, Jan C. Frijters, Richard Boada, Dina E. Hill, Maureen W. Lovett, E Mark Mahone, Erik G. Willcutt, Maryanne Wolf, John C. Defries, Alessandro Gialluisi, Clyde Francks, Simon E. Fisher, Richard K. Olson, Bruce F. Pennington, Shelley D. Smith, Joan Bosson-Heenan, Jeffrey R. Gruen
Multivariate Genome-Wide Association Study Of Rapid Automatised Naming And Rapid Alternating Stimulus In Hispanic American And African–American Youth, Dongnhu Thuy Truong, Andrew Kenneth Adams, Steven Paniagua, Jan C. Frijters, Richard Boada, Dina E. Hill, Maureen W. Lovett, E Mark Mahone, Erik G. Willcutt, Maryanne Wolf, John C. Defries, Alessandro Gialluisi, Clyde Francks, Simon E. Fisher, Richard K. Olson, Bruce F. Pennington, Shelley D. Smith, Joan Bosson-Heenan, Jeffrey R. Gruen
Psychology: Faculty Scholarship
Background: Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms.
Objective: To identify shared genetic factors that contribute to RAN and RAS performance using a multivariate approach.
Methods: We conducted a multivariate genome-wide association analysis of RAN Objects, RAN Letters and RAS Letters/Numbers in a sample of 1331 Hispanic American and African-American youth. Follow-up neuroimaging genetic analysis of cortical regions associated with reading …
Enrichment Of Putatively Damaging Rare Variants In The Dyx2 Locus And The Reading-Related Genes Ccdc136 And Flnc, Andrew K. Adams, Shelley D. Smith, Dongnhu T. Truong, Erik G. Willcutt, Richard K. Olson, John C. Defries, Bruce F. Pennington, Jeffrey R. Gruen
Enrichment Of Putatively Damaging Rare Variants In The Dyx2 Locus And The Reading-Related Genes Ccdc136 And Flnc, Andrew K. Adams, Shelley D. Smith, Dongnhu T. Truong, Erik G. Willcutt, Richard K. Olson, John C. Defries, Bruce F. Pennington, Jeffrey R. Gruen
Psychology: Faculty Scholarship
Eleven loci with prior evidence for association with reading and language phenotypes were sequenced in 96 unrelated subjects with significant impairment in reading performance drawn from the Colorado Learning Disability Research Center collection. Out of 148 total individual missense variants identified, the chromosome 7 genes CCDC136 and FLNC contained 19. In addition, a region corresponding to the well-known DYX2 locus for RD contained 74 missense variants. Both allele sets were filtered for a minor allele frequency ≤0.01 and high Polyphen-2 scores. To determine if observations of these alleles are occurring more frequently in our cases than expected by chance in …