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Disruptive Effects Of Aβ Oligomers To The Radial-Arm Maze Performance Of Rats, Kineta Lynn Morgan-Paisley
Disruptive Effects Of Aβ Oligomers To The Radial-Arm Maze Performance Of Rats, Kineta Lynn Morgan-Paisley
Dissertations
Converging lines of research have implicated a causal relationship between oligomers of amyloid-β and the cognitive impairments associated with Alzheimer's disease (AD); however, very few studies have provided direct experimental evidence of this relationship and none of those studies have used an established model of working memory. The present study used an established model of working memory, the radial-arm maze, to examine the effects of amyloid-β oligomers on the memory of two groups of rats. The experimental group received ICV injections of the culture media (CM) of Chinese Hamster Ovary (CHO) cells transfected with a human mutation of APP containing …