Psychology Commons^™

Meta-Analysis Of Rodent Behavior In Various Brain Injury And Disease Models, Earl C. Thorndyke Iii

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this study was to identify patterns and profiles present in rodent behavioral assay data to inform methodology of future animal research. Domains of spatial learning, motor function, activity, and emotionality were examined. This study first identified how rodent performance on commonly used behavioral and neurocognitive assays varies by species, sex, and age. Significant differences were observed in spatial learning curves, patterns of motor function, emotionality and activity in rats and mice. Overall, males and females had similar performances on spatial learning and motor function, but sex and species interactions were also observed, indicating varied sex differences in …