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Specific Dopaminergic Manipulation Of The Internal Clock Mechanism, Lianne Elizabeth Stanford
Specific Dopaminergic Manipulation Of The Internal Clock Mechanism, Lianne Elizabeth Stanford
Theses and Dissertations (Comprehensive)
Using non-specific dopaminergic agents, Meck (1983, 1986) and his colleagues have repeatedly demonstrated manipulations of the internal clock mechanism, while showing no other changes to the psychophysical function (DL & WF). The current study used analyses and procedures similar to those of Meck (1983) and investigated the internal clock mechanism with the specific D2 agonist, quinpirole. Two groups were trained with saline and tested with quinpirole (0.08 mg/kg). One group was naive to the drug prior to testing (DN), while the other had previous drug exposure (DE). A third group (DT) was trained with quinpirole, and tested with saline. The …
Animal Memory Processes For Number And Time: Pigeons, Methamphetamine, And The Internal Clock Model, James W. Coyle
Animal Memory Processes For Number And Time: Pigeons, Methamphetamine, And The Internal Clock Model, James W. Coyle
Theses and Dissertations (Comprehensive)
The mode-control model of counting and timing (Meek & Church, 1983) suggests that discriminations based on number and time may be controlled by the same internal clock mechanism. In Experiment 1, two groups of pigeons were initially trained to perform delayed symbolic matching-to-sample (DSMTS) at a 5s fixed baseline delay, with sample stimuli that consisted of sequences of flashing light. Testing was conducted with a range of delays (0, 2.5, 5, 7.5, and 10s). In the Number Group, control by number was established by varying the number of flashes while holding time constant. In the Time Group, control by time, …
Mk-801 Interferes With The Acquisition Of Amphetamine- And Lithium-Induced Place Conditioning, Jonathan Francis Toth
Mk-801 Interferes With The Acquisition Of Amphetamine- And Lithium-Induced Place Conditioning, Jonathan Francis Toth
Theses and Dissertations (Comprehensive)
The place conditioning paradigm was used to assess the ability of the noncompetitive NMDA receptor antagonist, M- 801 to interfere with drug-place associations. MK-801 (0.1 mg/kg, ip) attenuated a place preference produced by 10 mg/kg, but not by 3 or 5 mg/kg of amphetamine. MK-801 alone produced neither a place preference nor a place aversion. Interference with amphetamine place preference learning was not the result of state-dependent learning produced by MK-801. Furthermore, MK-801 did not interfere with the expression of a previously established amphetamine place preference. Pretreatment with MK-801 also interfered with lithium-induced conditioned place aversion learning. These results suggest …
Pentobarbital-Induced Place Aversion Learning, Gilbert Lew
Pentobarbital-Induced Place Aversion Learning, Gilbert Lew
Theses and Dissertations (Comprehensive)
Pentobarbital is self-administered by rats, but has also been reported to produce a conditioned place aversion. Since the self-administration and place preference paradigms both are considered to assess drug reward, we further examined the hedonic properties of pentobarbital using place conditioning. In Experiment 1, a dose of 15 mg/kg (ip) of pentobarbital produced a conditioned place aversion following 4 conditioning trials of various durations (5, 15, 30 or 60 min). Since rats are typically drug-experienced in the self-administration paradigm. Experiments 2 and 3 examined the effect of drug history on pentobarbital-induced place conditioning. Although preexposure to pentobarbital attenuated the place …