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Full-Text Articles in Psychology
Developmental Seizures And Mortality Result From Reducing Gabaa Receptor Α2-Subunit Interaction With Collybistin, Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
Developmental Seizures And Mortality Result From Reducing Gabaa Receptor Α2-Subunit Interaction With Collybistin, Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
Psychology Faculty Research
Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary methods we demonstrate an exclusive low micromolar binding of collybistin to the α2-subunit of GABAARs. To explore the biological relevance of collybistin-α2-subunit selectivity, we generate mice with a mutation in the α2-subunit-collybistin binding region (Gabra2-1). The mutation results in loss of a distinct subset of inhibitory synapses and decreased amplitude of inhibitory synaptic currents. Gabra2–1 mice have a striking phenotype characterized by increased susceptibility to seizures and early mortality. …
Six-To-One Gets The Job Done: Comments On The Reviews, W. Joseph Wyatt, Donna M. Midkiff
Six-To-One Gets The Job Done: Comments On The Reviews, W. Joseph Wyatt, Donna M. Midkiff
Psychology Faculty Research
We are pleased to note that six of the seven responses to our article were marked by approval, and/or thoughtful contemplation, regarding our central theses—that the research said to support biological causation of mental disorders is relatively weak, and that the claims of drug effectiveness are often overstated.
Biological Psychiatry: A Practice In Search Of A Science, W. Joseph Wyatt, Donna M. Midkiff
Biological Psychiatry: A Practice In Search Of A Science, W. Joseph Wyatt, Donna M. Midkiff
Psychology Faculty Research
The rise of the biological causation model in the past thirty years is traced to psychiatry’s efforts to regain lost status and to protect itself from intrusions by non-medical practitioners, as well as to the pharmaceutical industry’s drive for profits. Evidence in support of the model, including studies of identical twins and of brain structure and function, are less revealing than was earlier thought, due to problems in methodology and interpretation. Organized psychiatry, when challenged in 2003, was unable to provide compelling evidence for biological causation of most mental and behavioral disorders. A paradigm shift away from biological causation and …