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Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Graduate Theses, Dissertations, and Problem Reports
Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …