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A Genetically Informed Study Of Acute Threat Endophenotypes For Callous-Unemotional Traits, Ashlee A. Moore
A Genetically Informed Study Of Acute Threat Endophenotypes For Callous-Unemotional Traits, Ashlee A. Moore
Theses and Dissertations
Introduction. Callous-unemotional (CU) traits predict socially debilitating outcomes including Antisocial Personality Disorder and violent crime in adulthood. Despite significant research, the etiology of CU traits is not well understood. This dissertation incorporates genetic, physiological, neuroanatomical, and self-report measures to investigate the etiology of CU traits. Specifically, this project focuses on measures previously found to associate with impaired fear-processing observed in individuals high on CU. Brain morphometry for paralimbic regions of interest (ROIs) and electromyographic facial eyeblink reflex to startle and fear-potentiated startle probes were investigated as potential endophenotypes for CU traits. Methods. Two genetically informative (ages 9-20) twin samples ( …