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Full-Text Articles in Psychology
Opioid-Induced Respiratory Depression In C57bl/6j Mice: The Role Of Prefrontal Cortex Cholinergic Transmission In The Wakefulness Stimulus For Breathing, Wilton Sun
Select or Award-Winning Individual Scholarship
Opioid-induced respiratory depression (OIRD) is the primary cause of death from opioid overdose. Opioids depress breathing by diminishing the wakefulness stimulus for breathing in humans and mice. Cholinergic transmission in the prefrontal cortex (PFC) promotes cortical EEG activation, increases wakefulness, and stimulates breathing. However, no previous studies have tested whether increasing cholinergic transmission in the PFC can mitigate respiratory depression caused by systemically administered fentanyl in mice. The series of studies comprising this honors thesis is split into two phases. The first phase included a concentration response study evaluating the effects of fentanyl on breathing in C57BL/6J mice breathing room …
Effect Of Social Status On Behavioral And Neural Response To Stress, Daniel W. Curry, Kathleen E. Morrison, Matthew A. Cooper
Effect Of Social Status On Behavioral And Neural Response To Stress, Daniel W. Curry, Kathleen E. Morrison, Matthew A. Cooper
Senior Thesis Projects, 2009
Individuals respond differently to traumatic stress. Social status, which plays a key role in how animals experience and interact with their social environment, may influence how individuals respond to stressors. In this study, we used a conditioned defeat model to investigate whether social status alters susceptibility to the behavioral and neural consequences of traumatic stress. Conditioned defeat is a model in Syrian hamsters in which an acute social defeat encounter results in a long term increase in submissive behavior and a loss of normal territorial aggression. To establish social status, we weight matched and paired Syrian hamsters in daily aggressive …