Psychology Commons^™

Examination Of Methamphetamine Reinstatement In Female And Male Rats: A Pre-Clinical Model Of Relapse, Steven T. Pittenger

Department of Psychology: Dissertations, Theses, and Student Research

Methamphetamine (meth) dependence is often characterized by persistent and chronic relapse (i.e., return to drug use). There is growing pre-clinical and human evidence suggesting females are at greater risk to relapse. The set of studies presented in this dissertation extended this limited evidence by identifying sex-dependent neural substrates correlated with meth-triggered reinstatement (Experiment 1) and by examining sex-differences in reinstatement triggered by drugs of abuse that are commonly co-abused with meth (Experiment 2). Female and male rats were trained to self-administer meth, received subsequent extinction sessions, and then tested for reinstatement. In Experiment 1, rats were perfused following reinstatement testing …

The Contribution Of A Polygenic Risk Score To Individual Differences In Aggressive Behavior: The Moderating And Mediating Roles Of Stressful Events, Christa C. Christ

Department of Psychology: Dissertations, Theses, and Student Research

Although aggression can be beneficial in certain situations (e.g. playing sports, self-defense), excessive and inappropriate aggression can lead to adverse physical and psychological health outcomes in both perpetrators and victims. Genetic susceptibility to negative environments can increase the likelihood of aggressive behavior in the context of situational risk factors. Low efficiency of serotonin neurotransmission and exposure to stress appear to play a prominent role in the etiology of aggressive behavior. A set of three studies assessed the contribution of polygenic risk (TPH2 rs4570625, SLC6A4 5-HTTLPR+rs25531, HTR1B rs13212041, MAOA uVNTR) to aggressive behavior, including alcohol-related aggression, in university students at varying …

Double Dissociation Of The Anterior And Posterior Dorsomedial Caudate-Putamen In The Acquisition And Expression Of Associative Learning With The Nicotine Stimulus, Sergios Charntikov

Department of Psychology: Dissertations, Theses, and Student Research

Tobacco use is the leading cause of preventable deaths worldwide. This habit is not only debilitating to individual users but also to those around them (second-hand smoking). Nicotine is the main addictive component of tobacco products and is a moderate stimulant and a mild reinforcer. Importantly, besides its unconditional effects, nicotine also has conditioned stimulus effects that may contribute to the tenacity of the smoking habit. Because the neurobiological substrates underlying these processes are virtually unexplored, the present study investigated functional involvement of dorsomedial caudate putamen (dmCPu) in the conditioning processes with nicotine as a conditioned stimulus. Rats were trained …

Stress And Eyewitness Memory: Timing Of Stressor And Association With Cortisol Stress Responding, Timothy Ryan Robicheaux

Department of Psychology: Dissertations, Theses, and Student Research

Witnesses to and victims of criminal events can face significant stress during such encounters. Stress responding consists of a multitude of responses (e.g., anxiety, cardiovascular changes, cortisol responding). In the current study, I utilized a physiological stressor (i.e., the cold-pressor test) and a facial recognition paradigm to examine the relationship between cortisol change following stress exposure and memory accuracy. More specifically, I examined whether cortisol levels at specific memory stages (i.e., acquisition and retrieval) predicted stress responding differently.

Findings suggested that individual differences in cortisol stress responding to the cold-pressor test predicted facial recognition when peak cortisol was at a …

A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett

Department of Psychology: Dissertations, Theses, and Student Research

Smoking and tobacco dependence are serious health concerns in the United States and globally. Reward via the pharmacological effects of nicotine are believed to be the principal motivating factor that drive tobacco dependence. Research reveals differences in sensitivity between males and females to the motivational effects of nicotine in tobacco use. Enhancement of reinforcement value of non-nicotine rewards contributes to overall nicotine reward. Similar value-enhancing effects have been observed by the two most commonly prescribed smoking cessation aids, bupropion and varenicline. The present dissertation investigated the value-enhancing effects of nicotine, bupropion and varenicline in both male and female rats using …

Nonlinear Dynamics Of Infant Sitting Postural Control, Joan E. Deffeyes

Department of Psychology: Dissertations, Theses, and Student Research

Sitting is one of the first developmental milestones that an infant achieves. Thus measurements of sitting posture present an opportunity to assess sensorimotor development at a young age, in order to identify infants who might benefit from therapeutic intervention, and to monitor the efficacy of the intervention. Sitting postural sway data was collected using a force plate from infants with typical development, and from infants with delayed development, where the delay in development was due to cerebral palsy in most of the infants in the study. The center of pressure time series from the infant sitting was subjected to a …