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Full-Text Articles in Psychology
Systemic Growth Factor Increases As A Result Of Exercise May Reduce Alzheimer's Disease Risk In Midlife Mice And Humans, Amanda Hewes
Systemic Growth Factor Increases As A Result Of Exercise May Reduce Alzheimer's Disease Risk In Midlife Mice And Humans, Amanda Hewes
Electronic Theses and Dissertations
Alzheimer’s disease (AD) is a neurodegenerative disorder with insidious onset and slow progression. AD research has traditionally been based on neuronal and glial dysfunction due to hallmark beta-amyloid and tau pathologies. Although literature supports an association between AD and cardiovascular disease and/or cardiovascular risk factors, vascular dysfunction as an etiology of AD has been overlooked. Cardiovascular risk factors have been associated with both cardiovascular and cerebrovascular disease in midlife individuals, an age at which modifiable risk factor management may be the most beneficial. Up to half of AD cases worldwide and in the USA are attributable to modifiable risk factors. …
Characterization Of Ethanol-Related Phenotypic Differences Between C57bl/6j And C57bl/6nj Substrains: Role Of Cyfip2?, Matthew C. Hartmann
Characterization Of Ethanol-Related Phenotypic Differences Between C57bl/6j And C57bl/6nj Substrains: Role Of Cyfip2?, Matthew C. Hartmann
Electronic Theses and Dissertations
The C57BL/6 (B6) mouse is the most commonly used inbred strain in biomedical research, and has served as the basis for various large-scale genetic and genomic projects. Although the parental substrain, C57BL/6J (B6J), originated at The Jackson Laboratory, isolated breeding colonies are now maintained at numerous sites. This separation has resulted in genetic drift that has led to the emergence of phenotypic differences among these colonies. For instance, B6J mice display higher levels of voluntary ethanol consumption and increased locomotor responses to psychostimulants, relative to C57BL/6N mice (B6N). Initial progress has been made in elucidating the genetic bases of these …
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
Electronic Theses and Dissertations
Cancer patients treated with adjuvant chemotherapy often experience cognitive decline following treatment. This phenomenon, often dubbed “chemo brain” or “chemo fog” is usually temporary, but for a subset of survivors, these cognitive impairments can be long-lasting (>10 years) and negatively affect patients’ quality of life, career performance, and social fulfillment. While it is unclear what neurobiological mechanisms underlie chemotherapy related cognitive impairment, the majority of the animal literature has focused on adult neurogenesis. One process important for neurogenesis is the proliferation of new neurons within the dentate gyrus of the hippocampus. It is evident that many chemotherapy agents can …
Effects Of Neonatal Clomipramine Treatment On Photic And Non-Photic Circadian Phase Shifting In Rats, Suzanne M. Dwyer
Effects Of Neonatal Clomipramine Treatment On Photic And Non-Photic Circadian Phase Shifting In Rats, Suzanne M. Dwyer
Electronic Theses and Dissertations
Neonatal exposure to monoaminergic antidepressant drugs produces a wide variety of effects on the behavior and physiology of adult rats which parallel those observed in human depression. Monoaminergic neurotransmitter systems are involved in the regulation of both affective and circadian behaviors, and alterations in circadian rhythmicity have been observed in depressed patients and in several other animal depression models. The purpose of the present study was to explore circadian phase shifting following neonatal antidepressant treatment. Neonatal rats were divided into three treatment groups; a clomipramine-treated group, a saline-treated group, and an unhandled group. Daily injections of clomipramine (25 mg/kg SC), …