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Anxiety Symptoms As A Predictor Of Head And Neck Cancer Survival And Potential For Mediation By Cancer Treatment Response., Tyler D. Pollitt
Anxiety Symptoms As A Predictor Of Head And Neck Cancer Survival And Potential For Mediation By Cancer Treatment Response., Tyler D. Pollitt
College of Arts & Sciences Senior Honors Theses
BACKGROUND:
Head and neck cancers (HNC) are associated with high rates of depression, which seems to affect overall survival. However, little attention has been paid to the effects of anxiety on overall survival, though anxiety has been shown to activate inflammatory pathways implicated in cancer symptom development and progression. Here it was hypothesized that higher pre-treatment anxiety levels in HNC patients would predict poorer overall two-year survival and a higher likelihood of subsequent HNC treatment failure. Additionally, we expected that the relationship between higher pre-treatment anxiety and poorer two-year overall survival would be mediated by treatment failure.
METHODS:
Patients (n …