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Effects Of Amphetamine On Striatal Dopamine Release, Open-Field Activity, And Play In Fischer 344 And Sprague–Dawley Rats, Stephen M. Siviy, Lana S. Mcdowell, Samantha R. Eck, Alexandra Turano, Garnik Akopian, John P. Walsh
Effects Of Amphetamine On Striatal Dopamine Release, Open-Field Activity, And Play In Fischer 344 And Sprague–Dawley Rats, Stephen M. Siviy, Lana S. Mcdowell, Samantha R. Eck, Alexandra Turano, Garnik Akopian, John P. Walsh
Psychology Faculty Publications
Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning. To determine whether the dysfunctional play in this strain is associated with deficits in the handling and delivery of vesicular DA, the following experiments assessed the extent to which F344 rats are differentially sensitive to the effects of amphetamine. When exposed to amphetamine, striatal slices obtained from F344 rats showed a small increase in unstimulated DA release when compared with slices from Sprague–Dawley rats; they also showed a more rapid high …