Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Conditioned avoidance response (5)
- Sensitization (5)
- Adolescence (3)
- Clozapine (2)
- Phencyclidine (2)
-
- Prepulse inhibition (2)
- Risperidone (2)
- Tolerance (2)
- 22 kHz ultrasonic vocalization (1)
- 5-hydroxytryptamine 2A receptor (1)
- 5-hydroxytryptamine 2C receptor (1)
- Antipsychotic drug (1)
- Appetitive stimuli (1)
- C-Fos (1)
- CS1 and CS2 (1)
- Drug discrimination (1)
- Haloperidol (1)
- Locomotor activity (1)
- MDL100907 (1)
- MK212 (1)
- Maternal behavior (1)
- Maternal immune activation (1)
- Medial CPu (1)
- Motor activity (1)
- Neurotensin (1)
- Nicotine (1)
- Olanzapine (1)
- Pavlovian conditioning (1)
- Quetiapine (1)
- Quinpirole (1)
Articles 1 - 8 of 8
Full-Text Articles in Animal Studies
Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li
Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li
Department of Psychology: Faculty Publications
The present study characterized the behavioral mechanisms of avoidance–disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the …
Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li
Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li
Department of Psychology: Faculty Publications
Neurotensin is an endogenous neuropeptide closely associated with the mesolimbic dopaminergic system and shown to possess antipsychotic-like effects. In particular, acute neurotensin receptor activation can inhibit conditioned avoidance response (CAR), attenuate phencyclidine (PCP)-induced prepulse inhibition (PPI) disruptions, and reverse PCP-induced hyperlocomotion. However, few studies have examined the long term effects of repeated neurotensin receptor activation and results are inconsistent. Since clinical administration of antipsychotic therapy often requires a prolonged treatment schedule, here we assessed the effects of repeated activation of neurotensin receptors using an NTS1 receptor selective agonist, PD149163, in 3 behavioral tests of antipsychotic activity. We also investigated whether …
Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li
Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li
Department of Psychology: Faculty Publications
Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test.We also examined howthese two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump(HAL-0.25 CONT; 0.25mgkg−1 day−1, …
Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li
Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li
Department of Psychology: Faculty Publications
Rationale Risperidone use in children and adolescents for the treatment of various neuropsychiatric disorders (e.g., schizophrenia, autism, disruptive behavior, etc.) has increased substantially in recent decades. However, its long-term effect on the brain and behavioral functions is not well understood. Objective The present study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response in adulthood in the conditioned avoidance response and phencyclidine (PCP)-induced hyperlocomotion tests. Methods Male adolescent Sprague-Dawley rats (postnatal days [P] 40–44 or 43–48) were first treated with risperidone (0.3, 0.5, or 1.0 mg/kg, subcutaneously (sc)) and tested in the conditioned avoidance or PCP (3.2 mg/kg, …
Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li
Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li
Department of Psychology: Faculty Publications
Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression – and its known interaction with dopamine – it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study,we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats.We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT …
Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li
Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li
Department of Psychology: Faculty Publications
This preclinical study investigated howa short-termrisperidone treatment in adolescence impacts antipsychotic response to olanzapine and clozapine in adulthood. Antipsychotic effect was indexed by a drug's suppressive effect on avoidance responding in a rat conditioned avoidance response (CAR) model. Male adolescent Sprague–Dawley rats were first treated with risperidone (1.0mg/kg, sc) or sterile water and tested in the CAR model for 5 consecutive days from postnatal days P 40 to 44. After they became adults (~P 80–84), they were switched to olanzapine (0.5mg/kg, sc), clozapine (5.0mg/kg, sc) or vehicle treatment and tested for avoidance for 5 days. During the adolescent period, repeated …
When Will We Meet Again? Regularities Of Social Connectivity As Reflected In Memory And Decision Making, Thorsten Pachur, Lael J. Schooler, Jeffrey R. Stevens
When Will We Meet Again? Regularities Of Social Connectivity As Reflected In Memory And Decision Making, Thorsten Pachur, Lael J. Schooler, Jeffrey R. Stevens
Department of Psychology: Faculty Publications
In 1967, the social psychologist Stanley Milgram reported a fascinating observation. For a study on social connectivity, he randomly picked several individuals in Wichita, Kansas, and asked them to get a message delivered to a particular target person in Cambridge, Massachusetts—a distance of more than 1,300 miles. There were two catches. First, Milgram provided no address but only the name and some basic information about the target person, such as the area where he lived and his profession (the target person was the same for everybody). Second, people could only forward the message to someone they knew on a firstname …
Conditioned Response Evoked By Nicotine Conditioned Stimulus Preferentially Induces C-Fos Expression In Medial Regions Of Caudate-Putamen, Sergios Charntikov, Matthew E. Tracy, Changjiu Zhao, Ming Li, Rick A. Bevins
Conditioned Response Evoked By Nicotine Conditioned Stimulus Preferentially Induces C-Fos Expression In Medial Regions Of Caudate-Putamen, Sergios Charntikov, Matthew E. Tracy, Changjiu Zhao, Ming Li, Rick A. Bevins
Department of Psychology: Faculty Publications
Nicotine has both unconditioned and conditioned stimulus properties. Conditioned stimulus properties of nicotine may contribute to the tenacity of nicotine addiction. The purpose of this experiment was to use neurohistochemical analysis of rapidly developing c-Fos protein to elucidate neurobiological loci involved in the processing of nicotine as an interoceptive conditioned stimulus (CS). Rats were injected (SC) in an intermixed fashion with saline or nicotine (16 sessions of each) and placed in conditioning chambers where they were given one of the three conditions depending on group assignment: (a) nicotine paired 100% of the time with intermittent access to sucrose (nicotine-CS condition), …