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Full-Text Articles in Animal Studies
055— Ketogenic Diet And Dendritic Morphology In A Mouse Model Of Repetitive Behavior, Samantha Seeger, Yume Iriyama, Allison R. Bechard
055— Ketogenic Diet And Dendritic Morphology In A Mouse Model Of Repetitive Behavior, Samantha Seeger, Yume Iriyama, Allison R. Bechard
GREAT Day Posters
Repetitive motor behaviors are invariant movements with no apparent function. They are associated with several disorders, including autism spectrum disorders (ASD). However, little is known about the causes of these restricted behavior patterns, and effective treatments are lacking. ASD has recently been treated with a ketogenic diet (KD). Now a popular fad, KD is a high-fat, low-carb diet that has treated intractable epilepsy for decades. However, the mechanisms mediating KD’s beneficial effects are still unclear. We first show KD can attenuate repetitive circling behavior. We then assessed dendritic spine density in the left and right dorsolateral striatum as a potential …
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
GREAT Day Posters
Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive …
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
GREAT Day Posters
Exposure to trauma is a risk factor for substance use disorders. Using a mouse model of PTSD, we tested the effects of exposure to a stressor (synthetic fox pheromone: TMT) on response to cocaine. Cocaine induced locomotion and cocaine seeking behavior in a conditioned place preference (CPP) were assessed. TMT was an effective stressor, indicated by freezing behavior, which is a known fear response in mice. In both males and females, TMT-exposed mice showed a greater locomotor response to cocaine compared to control mice, resulting in the interaction between time and TMT treatment. TMT-exposed males, but not females, were overall …
130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano
130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano
GREAT Day Posters
Now a popular fad diet, the ketogenic diet (KD) is a high-fat, low-carb diet that for decades has been used for treatment of intractable epilepsy. Recent therapeutic applications of KD in animal models include treatment of dementia, obsessive-compulsive disorder, and autism. These disorders are associated with stereotypic behaviors (repetitive, invariant behaviors with no apparent function) that are life-impairing and stigmatizing. However, little is known about their underlying mechanisms and no effective pharmacological treatments are available. Here, we present a novel application of KD to reduce stereotypic behavior in an inbred strain of mice (FVBN/J) that displays a prominent repetitive circling …
416— The Effects Of Early Life Trauma On Anxiety And Alcohol Use Is Modified By Environment, Katie Kompanijec, Keara Mullin, Gavin Vaughan, Melissa Herman, Allison Bechard
416— The Effects Of Early Life Trauma On Anxiety And Alcohol Use Is Modified By Environment, Katie Kompanijec, Keara Mullin, Gavin Vaughan, Melissa Herman, Allison Bechard
GREAT Day Posters
Early life trauma is a risk factor for later anxiety and alcohol use disorders. However, the role of the post-trauma environment on the development of such disorders is not well understood. In the present study we investigated experience-dependent changes in anxiety and alcohol use after exposure to early trauma. Young mice (day 23) were exposed to a predator odor (synthetic fox pheromone, TMT) and then reared in either standard (SE) or enriched environments (EE). Adolescent anxiety and conditioned fear were reduced in EE-males, but not EE-females. Adult mice were then tested for their preference to drink alcohol. Alcohol intake escalated …
159— The Effects Of Trauma On The Response To Cocaine, Gavin Vaughan, Melissa Herman, Katie Kompanijec, Maren Hogan, Annaclaire Modico, Keara Mullin, Allison R. Bechard Ph.D.
159— The Effects Of Trauma On The Response To Cocaine, Gavin Vaughan, Melissa Herman, Katie Kompanijec, Maren Hogan, Annaclaire Modico, Keara Mullin, Allison R. Bechard Ph.D.
GREAT Day Posters
Exposure to adverse events is a risk factor for substance use disorder. We modeled this in an inbred strain of mice by exposing adult males to a predator odor (a synthetic fox pheromone, TMT) and then assessing 1. Cocaine-induced locomotion, and 2. Conditioned place preference (CPP) of cocaine. TMT was an effective stressor as indicated by freezing behavior, an absence of movement that is an instinctive fear response in mice. Interestingly, in a 1-hour baseline locomotor test, TMT-exposed (TMT+) mice were more active than non-exposed (TMT-) mice. In addition, following a cocaine (10 mg/kg) injection (i.p.) TMT+ mice showed a …
161— The Effects Of Environment On The Development Of Cocaine-Seeking, Gavin Vaughan, Akane Ichiki, Shreyya Malik, Allison R. Bechard
161— The Effects Of Environment On The Development Of Cocaine-Seeking, Gavin Vaughan, Akane Ichiki, Shreyya Malik, Allison R. Bechard
GREAT Day Posters
Cocaine addiction is a major individual and societal issue. This study aimed to investigate the environmental and social factors that influence the development of cocaine addiction. Mice were reared in either standard housing or enriched housing. Cocaine preference was measured using the Conditioned Place Preference paradigm, in which subjects are conditioned to associate an injection of cocaine (20mg/kg. I.P.) with a particular side of a 3 chambered arena. Subjects reared in enriched environments displayed increased preference for cocaine in cue primed tests. All subjects displayed cocaine preference in cocaine primed tests. This may be attributed to the enhanced memory that …