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Full-Text Articles in Social and Behavioral Sciences

Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie Nov 2012

Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie

Jimmy Chun Yu Louie

In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …


Consumer Response To Healthy Eating, Physical Activity And Weight-Related Recommendations: A Systematic Review, S Boylan, Jimmy Chun Yu Louie, T Gill Nov 2012

Consumer Response To Healthy Eating, Physical Activity And Weight-Related Recommendations: A Systematic Review, S Boylan, Jimmy Chun Yu Louie, T Gill

Jimmy Chun Yu Louie

Strong evidence linking poor diet and lack of physical activity to risk of obesity and related chronic disease has supported the development and promotion of guidelines to improve population health. Still, obesity continues to escalate as a major health concern, and so the impact of weight-related guidelines on behaviour is unclear. The aim of this review was to examine consumer response to weight-related guidelines. A systematic literature search was performed using Medline, PsycInfo, ProQuest Central and additional searches using Google and reference lists. Of the 1,765 articles identified, 46 relevant titles were included. Most studies examined attitudes towards content, source, …


Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell Jul 2012

Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell

L. C. Tapsell

Background: Knowing the total energy expenditure (TEE) of overweight adults is important for prescribing weight loss interventions. However, objective measurements of TEE may not always be readily available and can be expensive. This study aimed to investigate the validity of RT3 accelerometers in predicting the TEE of sedentary overweight adults, and to identify any sensitivity to anthropometric changes. Methods: The analysis used data from a 12-week weight loss study. At baseline and 12-week, TEE was predicted using RT3 accelerometers during whole room calorimeter stays. Bias between 2 methods was compared at and between the baseline and 12-week measurement points. Multiple …


Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele Jun 2012

Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele

A. D. Okely

It has been speculated that high plantar pressures might cause foot pain and discomfort which, in turn, may discourage children from being physically active and result in them spending more time in sedentary activities. The purpose of this study was to determine whether plantar pressure distributions generated by preschool children were correlated with objectively measured time spent in physical activity and sedentary behaviour. Dynamic plantar pressures were measured for 33 preschool children (age = 4.3±0.6 years; height = 1.06±0.1 m; mass = 18.4±2.9 kg; 17 boys) as they walked across an emed AT-4 pressure platform. Physical activity was objectively assessed …


Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson Jun 2012

Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson

Don C. Iverson

Background Evidence is growing on the benefit of physical activity to improve well-being following a cancer diagnosis. This study examined changes in physical activity from pre to post diagnosis and explored this relationship with quality of life and depression. Methods Participants were recruited by posters and by letter of invitation. The questionnaire was completed by 59 prostate and 32 breast cancer survivors. Results Physical activity decreased by 72 minutes per week from pre to post diagnosis, although 20.9% reported having increased activity post diagnosis. Over 30% were considered depressed. Breast cancer participants who increased physical activity post diagnosis reported higher …


Do Australian Primary School Environments Affect Children's Playground Physical Activity Levels?, Anne-Maree Parrish, Donald Iverson, Kenneth Russell, Heather Yeatman Jun 2012

Do Australian Primary School Environments Affect Children's Playground Physical Activity Levels?, Anne-Maree Parrish, Donald Iverson, Kenneth Russell, Heather Yeatman

Don C. Iverson

No abstract provided.


Sleep Quality, Fatigue And Physical Activity Following A Cancer Diagnosis, Nancy Humpel, Donald Iverson Jun 2012

Sleep Quality, Fatigue And Physical Activity Following A Cancer Diagnosis, Nancy Humpel, Donald Iverson

Don C. Iverson

Research on physical activity for cancer survivors suggests a relationship with improved quality of life. The aim of this study was to explore if there was also a relationship of physical activity with sleep difficulties and fatigue, common effects of cancer and its treatments. Recruitment was by posters and flyers in medical waiting rooms and by letter of invitation. Thirty-two breast and 59 prostate cancer survivors completed the questionnaire. Poor sleep quality was reported by 57.8%. A greater proportion of breast cancer (36.7%) than prostate cancer survivors (15.5%) reported poor sleep latency, and sleep disturbance (48.4% vs. 17.2%). The mean …


The Promotion Of Physical Activity In The United States, Donald Iverson, Jonathan Fielding, Richard Crow, Gregory Christenson Jun 2012

The Promotion Of Physical Activity In The United States, Donald Iverson, Jonathan Fielding, Richard Crow, Gregory Christenson

Don C. Iverson

While the medical care encounter is considered an ideal situation in which patients are encouraged to increase their physical activity levels, very little research has been conducted in this setting. In fact, with the exception of the physical activity components of cardiac rehabilitation programs, few formal physical activity programs are available in medical care settings. Although the workplace is currently the focus of the greatest interest by those persons who implement physical activity programs, there is little precision in defining what constitutes a worksite physical activity program. A number of researchers and authors, using program experience rather than empirical findings, …


Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell Jun 2012

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Don C. Iverson

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …


Emg Activity And Total Work Reduction In Occluded And Non-Occluded Resistance Exercise Conditions, John Sampson, Herbert Groeller, Darryl Mcandrew, Heath Kilah Jan 2012

Emg Activity And Total Work Reduction In Occluded And Non-Occluded Resistance Exercise Conditions, John Sampson, Herbert Groeller, Darryl Mcandrew, Heath Kilah

John Sampson

No abstract provided.


The Effect Of Elbow Flexion Speed And Partial Limb Occlusion On Emg Activity, John Sampson, Herbert Groeller, Darryl Mcandrew, R Achttien, J Stege Jan 2012

The Effect Of Elbow Flexion Speed And Partial Limb Occlusion On Emg Activity, John Sampson, Herbert Groeller, Darryl Mcandrew, R Achttien, J Stege

John Sampson

This investigation aimed to determine the neuromuscular response of the bicep brachii during heavy (6RM) dynamic resistance exercise performed to volitional exhaustion. Electromyographic (EMG) activity was compared in twelve male subjects performing dominant-limb elbow flexion exercise during four conditions: i) Explosive concentric and eccentric (SSC); ii) Explosive concentric, control eccentric (EC); iii) control (C); and iv) control with limb occlusion (CO) (110mmHg). CO and SSC are reported to increase motor unit activity when compared to control exercise (2 second flexion, 2 second extension). It was hypothesised that EMG activity will be higher in conditions of explosive exercise. Surface EMG activity …


Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell Jan 2012

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Faculty of Health and Behavioural Sciences - Papers (Archive)

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …


The Impact Of Complex Survey Design On Prevalence Estimates Of Intakes Of Food Groups In The Australian National Children's Nutrition And Physical Activity Survey, Sandy Burden, Yasmine Probst, David G. Steel, Linda C. Tapsell Jan 2012

The Impact Of Complex Survey Design On Prevalence Estimates Of Intakes Of Food Groups In The Australian National Children's Nutrition And Physical Activity Survey, Sandy Burden, Yasmine Probst, David G. Steel, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.


C-Amp Dependent Protein Kinase A Inhibitory Activity Of Six Algal Extracts From South Eastern Australia And Their Fatty Acid Composition, Ana Zivanovic, Danielle Skropeta Jan 2012

C-Amp Dependent Protein Kinase A Inhibitory Activity Of Six Algal Extracts From South Eastern Australia And Their Fatty Acid Composition, Ana Zivanovic, Danielle Skropeta

Faculty of Science, Medicine and Health - Papers: part A

c-AMP dependent protein kinase (protein kinase A, PKA) is an important enzyme involved in the regulation of an increasing number of physiological processes including immune function, cardiovascular disease, memory disorders and cancer. The objective of this study was to evaluate the PKA inhibitory activity of a range of algal extracts, along with their fatty acid composition. Six algal species were investigated including two Chlorophyta (Codium dimorphum and Ulva lactuca), two Phaeophyta (Phyllospora comosa and Sargassum sp.) and two Rhodophyta (Prionitis linearis and Corallina vancouveriensis), with the order of PKA inhibitory activity of their extracts identified as follows: brown seaweeds > red …


Bioregional Assessment Project: Sydney Metropolitan, Southern Rivers And Hawkesbury-Nepean Catchments: Data Collation Phase To Study The Impact Of Mining Activity And Coal Seam Gas On Environmental Assets, John Bradd, Tim Cohen, Sam Marx, Sol Buckman, Emma Burkhardt, A Clarke, Nicole Cook, Stephen Cullen, James Daley, Alexi Gavin, Ren Hu, Emma Kiekebosch-Fitt, Matt Lemcke, Andrew Lowe, Thomas Mcmahon, Luke Mcneilage, Kaitlyn O'Mara, Garth Nagle, Sam Robson, Carolyn Silveri, Joe Stammers Jan 2012

Bioregional Assessment Project: Sydney Metropolitan, Southern Rivers And Hawkesbury-Nepean Catchments: Data Collation Phase To Study The Impact Of Mining Activity And Coal Seam Gas On Environmental Assets, John Bradd, Tim Cohen, Sam Marx, Sol Buckman, Emma Burkhardt, A Clarke, Nicole Cook, Stephen Cullen, James Daley, Alexi Gavin, Ren Hu, Emma Kiekebosch-Fitt, Matt Lemcke, Andrew Lowe, Thomas Mcmahon, Luke Mcneilage, Kaitlyn O'Mara, Garth Nagle, Sam Robson, Carolyn Silveri, Joe Stammers

Faculty of Science, Medicine and Health - Papers: part A

This study was commissioned by the Hawkesbury-Nepean (HNCMA), Sydney Metropolitan (SMCMA) and Southern Rivers (SRCMA) Catchment Management Authorities and undertaken by the University of Wollongong to collate existing data and to provide a preliminary assessment of the potential impacts of coal seam gas (CSG) and coal mining activities on environmental assets within the three CMA regions, where environmental assets were defined under three broad themes; water, land and biodiversity. This study formed part of the Australian Federal Government’s Department of Sustainability, Environment, Water, Population and Communities (SEWPaC) Bioregional Assessment initiative within regions potentially affected by CSG and coal mining activities. …


An Indoor Localisation And Motion Monitoring System To Determine Behavioural Activity In Dementia Afflicted Patients In Aged Care, Matthew D'Souza, Montserrat Ros, Mohanraj Karunanithi Jan 2012

An Indoor Localisation And Motion Monitoring System To Determine Behavioural Activity In Dementia Afflicted Patients In Aged Care, Matthew D'Souza, Montserrat Ros, Mohanraj Karunanithi

Faculty of Health and Behavioural Sciences - Papers (Archive)

Dementia is highly prevalent among the older population. Most patients with dementia are admitted to an aged care facility due to wandering behaviour which tends to result in dangerous scenarios such as straying away from the facility and being seriously injured. Due to the decreasing availability of carers in aged care, there is a need to prioritise monitoring of patients that have a severe case of wondering. The challenge is to allow carers to monitor the status of such patients in terms of position localisation and motion behavioural status, in real-time. The long term behavioural analysis of such patients would …


Physical Activity And Energy Expenditure In Haemodialysis Patients: An International Survey, Carla Maria Avesani, Stanislas Trolonge, Patrik Deleaval, Flavia Baria, Denise Mafra, Gerd Faxen-Irving, Phillipe Chauveau, Daniel Teta, Maria Ayako Kamimura, Maria Chan, Lilian Cuppari, Olof Heimburger, Denis Fouque Jan 2012

Physical Activity And Energy Expenditure In Haemodialysis Patients: An International Survey, Carla Maria Avesani, Stanislas Trolonge, Patrik Deleaval, Flavia Baria, Denise Mafra, Gerd Faxen-Irving, Phillipe Chauveau, Daniel Teta, Maria Ayako Kamimura, Maria Chan, Lilian Cuppari, Olof Heimburger, Denis Fouque

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background. The assessment of physical activity and energy expenditure is relevant to the care of maintenance haemodialysis (MHD) patients. In the current study, we aimed to evaluate measurements of physical activity and energy expenditure in MHD patients from different centres and countries and explored the predictors of physical activity in these patients. Methods. In this cross-sectional multicentre study, 134MHD patients from four countries (France, Switzerland, Sweden and Brazil) were included. The physical activity was evaluated for 5.0 6 1.4 days (mean 6 SD) by a multisensory device (SenseWear Armband) and comprised the assessment of number of steps per day, activity-related …


Influence Of 18ghz Microwave Radiation On The Enzymatic Activity Of Escherichia Coli Lactate Dehydrogenase And Cytochrome C Oxidase, Yuri Shamis, Alex Traub, Rodney J. Croft, Russell Crawford, Elena Ivanova Jan 2012

Influence Of 18ghz Microwave Radiation On The Enzymatic Activity Of Escherichia Coli Lactate Dehydrogenase And Cytochrome C Oxidase, Yuri Shamis, Alex Traub, Rodney J. Croft, Russell Crawford, Elena Ivanova

Faculty of Health and Behavioural Sciences - Papers (Archive)

The catalytic activity of two common bacterial enzymes, lactate dehydrogenase (LDH) and cytochrome c oxidase (COX) from Escherichia coli, was examined following bacterial exposure to microwave (MW) radiation under well-defined experimental conditions. The experiments were conducted in a specialised microwave processing apparatus, with an exposure frequency of 18 GHz, and a temperature profile that was restricted to below 40oC to avoid thermal degradation of the bacteria. The absorbed power was calculated to be 1500 kW/m3 and the electric field was determined to be 300 V/m. Both values were theoretically confirmed using Computer Simulation Technology (CST) Microwave Studio 3D Electromagnetic Stimulation …


Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell Jan 2011

Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: Knowing the total energy expenditure (TEE) of overweight adults is important for prescribing weight loss interventions. However, objective measurements of TEE may not always be readily available and can be expensive. This study aimed to investigate the validity of RT3 accelerometers in predicting the TEE of sedentary overweight adults, and to identify any sensitivity to anthropometric changes. Methods: The analysis used data from a 12-week weight loss study. At baseline and 12-week, TEE was predicted using RT3 accelerometers during whole room calorimeter stays. Bias between 2 methods was compared at and between the baseline and 12-week measurement points. Multiple …


Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele Jan 2011

Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele

Faculty of Health and Behavioural Sciences - Papers (Archive)

It has been speculated that high plantar pressures might cause foot pain and discomfort which, in turn, may discourage children from being physically active and result in them spending more time in sedentary activities. The purpose of this study was to determine whether plantar pressure distributions generated by preschool children were correlated with objectively measured time spent in physical activity and sedentary behaviour. Dynamic plantar pressures were measured for 33 preschool children (age = 4.3±0.6 years; height = 1.06±0.1 m; mass = 18.4±2.9 kg; 17 boys) as they walked across an emed AT-4 pressure platform. Physical activity was objectively assessed …


Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson Jan 2011

Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background Dairy products have been perceived as having the potential to cause adverse effects in individuals with Crohn’s disease (CD) and are often avoided, potentially increasing the risk of osteoporosis and related morbidity associated with inadequate dietary calcium intake. Objective To evaluate the self-reported effects of dairy products on CD symptoms and to determine whether these effects differed between types of dairy products consumed and disease state or location. Design Secondary analysis of dietary survey and clinical data from participants in the Genes and Diet in Inflammatory Bowel Disease study based in Auckland, New Zealand. Subjects/setting One hundred and sixty-five …


Declining Physical Activity Levels As An Unintended Consequence Of Abolishing Mandatory Campus Service Fees, Sandra C. Jones, Lance R. Barrie Jan 2011

Declining Physical Activity Levels As An Unintended Consequence Of Abolishing Mandatory Campus Service Fees, Sandra C. Jones, Lance R. Barrie

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: This study investigates the effect of the introduction of voluntary student unionism and subsequent increase in campus facility fees on engagement in physical activity on campus. Participants: Participants were 1,904 students from a large regional NSW (Australia) university across 3 time periods (926 in 2005, 504 in 2006, and 474 in 2007). Methods: Students completed a survey across the 3 time periods, responding to questions about physical activity levels, use of on-campus and off-campus facilities, and barriers to facility use. Results: Participation in physical activity at university facilities was low overall, and declined substantially between 2005 and 2007, with …


Beat It: Diabetes Lifestyle And Physical Activity Program - The Effects And Affordability Of A 12-Week Community Based, Physical Activity Program For People With Or At Risk Of Diabetes, Bronwyn Penny, Joel Tuccia, Marc A. Brown Jan 2010

Beat It: Diabetes Lifestyle And Physical Activity Program - The Effects And Affordability Of A 12-Week Community Based, Physical Activity Program For People With Or At Risk Of Diabetes, Bronwyn Penny, Joel Tuccia, Marc A. Brown

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.


Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie Jan 2008

Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie

Faculty of Health and Behavioural Sciences - Papers (Archive)

In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …


Evaluating The Impact Of The Environment On The Physical Activity Levels Of People With Dementia In Aged Care Facilities, Loren Devries, Victoria Traynor, Nancy Humpel Jan 2008

Evaluating The Impact Of The Environment On The Physical Activity Levels Of People With Dementia In Aged Care Facilities, Loren Devries, Victoria Traynor, Nancy Humpel

Faculty of Health and Behavioural Sciences - Papers (Archive)

To evaluate the impact of the environment on the physical activity levels of people with dementia living in residential aged care facilities


Do Australian Primary School Environments Affect Children's Playground Physical Activity Levels?, Anne-Maree Parrish, Donald Iverson, Kenneth Russell, Heather Yeatman Jan 2008

Do Australian Primary School Environments Affect Children's Playground Physical Activity Levels?, Anne-Maree Parrish, Donald Iverson, Kenneth Russell, Heather Yeatman

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.


Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson Jan 2007

Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background Evidence is growing on the benefit of physical activity to improve well-being following a cancer diagnosis. This study examined changes in physical activity from pre to post diagnosis and explored this relationship with quality of life and depression. Methods Participants were recruited by posters and by letter of invitation. The questionnaire was completed by 59 prostate and 32 breast cancer survivors. Results Physical activity decreased by 72 minutes per week from pre to post diagnosis, although 20.9% reported having increased activity post diagnosis. Over 30% were considered depressed. Breast cancer participants who increased physical activity post diagnosis reported higher …


Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson Jan 2007

Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson

Faculty of Health and Behavioural Sciences - Papers (Archive)

INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …


Scaling Of Na+, K+-Atpase Molecular Activity And Membrane Fatty Acid Composition In Mammalian And Avian Hearts, Anthony J. Hulbert, Paul Else, Kurt Haga, Nigel Turner Jan 2006

Scaling Of Na+, K+-Atpase Molecular Activity And Membrane Fatty Acid Composition In Mammalian And Avian Hearts, Anthony J. Hulbert, Paul Else, Kurt Haga, Nigel Turner

Faculty of Health and Behavioural Sciences - Papers (Archive)

We have examined Na+,K+‐ATPase molecular activity and membrane fatty acid composition in the heart of six mammalian and eight avian species ranging in size from 30 g in mice to 280 kg in cattle and 13 g in zebra finches to 35 kg in emus, respectively. Na+,K+‐ATPase activity scaled negatively with body mass in both mammals and birds. In small mammals, the elevated enzyme activity was related to allometric changes in both the concentration and molecular activity (turnover rate) of Na+,K+‐ATPase enzymes, while in small birds, higher Na …


An Allometric Comparison Of Microsomal Membrane Lipid Composition And Sodium Pump Molecular Activity In The Brain Of Mammals And Birds, Anthony J. Hulbert, Paul Else, Nigel Turner Jan 2005

An Allometric Comparison Of Microsomal Membrane Lipid Composition And Sodium Pump Molecular Activity In The Brain Of Mammals And Birds, Anthony J. Hulbert, Paul Else, Nigel Turner

Faculty of Health and Behavioural Sciences - Papers (Archive)

Previous research has shown that the lipid milieu surrounding membrane proteins may be an important factor in determining their activity. To investigate this we have examined sodium pump molecular activity and microsomal membrane lipid composition in the brain of five mammalian and eight avian species ranging in size from 30 g mice to 280 kg cattle and 13 g zebra finches to 35 kg emus, respectively. Sodium pump (Na+,K+-ATPase) activity was higher in the smaller species and showed a significant allometric decline with body mass in both the mammals (μmol Pi h-1 mg wet …