Social and Behavioral Sciences Commons^™

Behavioral, Perceptual, And Neural Alterations In Sensory And Multisensory Function In Autism Spectrum Disorder., Sarah H Baum, Ryan A Stevenson, Mark T Wallace

Brain and Mind Institute Researchers' Publications

Although sensory processing challenges have been noted since the first clinical descriptions of autism, it has taken until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 for sensory problems to be included as part of the core symptoms of autism spectrum disorder (ASD) in the diagnostic profile. Because sensory information forms the building blocks for higher-order social and cognitive functions, we argue that sensory processing is not only an additional piece of the puzzle, but rather a critical cornerstone for characterizing and understanding ASD. In this review we discuss what …

Dual Optimization Method Of Radiofrequency And Quasistatic Field Simulations For Reduction Of Eddy Currents Generated On 7t Radiofrequency Coil Shielding., Yujuan Zhao, Tiejun Zhao, Shailesh B Raval, Narayanan Krishnamurthy, Hai Zheng, Chad T Harris, William B Handler, Blaine A Chronik, Tamer S Ibrahim

Brain and Mind Institute Researchers' Publications

PURPOSE: To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms.

METHODS: One set of a four-element, 2 × 2 Tic-Tac-Toe head coil structure was selected and constructed to study eddy currents on the RF coil shielding. The generated eddy currents were quantitatively studied in the time and frequency domains. The RF characteristics were studied using the finite difference time domain method. Five different kinds of RF shielding were tested on a 7T MRI scanner with phantoms and in vivo human subjects. …

Albumin Administration In Acute Ischemic Stroke: Safety Analysis Of The Alias Part 2 Multicenter Trial, Michael D. Hill, Renee H. Martin, Yuko Y. Palesch, Claudias S. Moy, Diego Tamariz, Karla J. Ryckborst, Elizabeth B. Jones, David Weisman, L. Creed Pettigrew, Myron D. Ginsberg

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Albumin treatment of ischemic stroke was associated with cardiopulmonary adverse events in previous studies and a low incidence of intracranial hemorrhage. We sought to describe the neurological and cardiopulmonary adverse events in the ALIAS Part 2 Multicenter Trial.

METHODS: Ischemic stroke patients, aged 18-83 and a baseline NIHSS ≥ 6, were randomized to treatment with ALB or saline control within 5 hours of stroke onset. Neurological adverse events included symptomatic intracranial hemorrhage, hemicraniectomy, neurological deterioration and neurological death. Cardiopulmonary adverse events included pulmonary edema/congestive heart failure, acute coronary syndromes, atrial fibrillation, pneumonia and pulmonary thromboembolism.

RESULTS: …

Tract-Based Spatial Statistics In Preterm-Born Neonates Predicts Cognitive And Motor Outcomes At 18 Months., E G Duerden, J Foong, V Chau, H Branson, K J Poskitt, R E Grunau, A Synnes, J G Zwicker, S P Miller

Brain and Mind Institute Researchers' Publications

BACKGROUND AND PURPOSE: Adverse neurodevelopmental outcome is common in children born preterm. Early sensitive predictors of neurodevelopmental outcome such as MR imaging are needed. Tract-based spatial statistics, a diffusion MR imaging analysis method, performed at term-equivalent age (40 weeks) is a promising predictor of neurodevelopmental outcomes in children born very preterm. We sought to determine the association of tract-based spatial statistics findings before term-equivalent age with neurodevelopmental outcome at 18-months corrected age.

MATERIALS AND METHODS: Of 180 neonates (born at 24-32-weeks' gestation) enrolled, 153 had DTI acquired early at 32 weeks' postmenstrual age and 105 had DTI acquired later at …

Acceptance And Commitment Therapy (Act) For Psychological Adjustment After Traumatic Brain Injury: Reporting The Protocol For A Randomised Controlled Trial, Diane L. Whiting, Grahame K. Simpson, Hamish J. Mcleod, Frank P. Deane, Joseph Ciarrochi

joseph Ciarrochi

Following a severe traumatic brain injury (TBI) there is a complex presentation of psychological symptoms which may impact on recovery. Validated treatments addressing these symptoms for this group of people are limited. This article reports on the protocol for a single-centre, two-armed, Phase II Randomised Control Trial (RCT) to address the adjustment process following a severe TBI. Participants will be recruited from Liverpool Brain Injury Rehabilitation Unit and randomly allocated to one of two groups, Acceptance and Commitment Therapy (ACT) or an active control (Befriending). The active treatment group utilises the six core processes of ACT with the intention of …

Assessing The Feasibility Of Acceptance And Commitment Therapy In Promoting Psychological Adjustment After Severe Traumatic Brain Injury, Diane Whiting, Grahame Simpson, Joseph Ciarrochi, Hamish Mcleod

joseph Ciarrochi

This study evaluated the feasibility of a treatment program utilising Acceptance and Commitment Therapy (ACT) to address psychological adjustment to severe traumatic brain injury (TBI). ACT focuses on persons’ relationship with internal experiences such as thoughts, emotions and memories in order for them to live a life consistent with their values. Treatment goals include increasing psychological flexibility, participation in valued life roles and reducing psychological distress. Method: Two participants (both male, P1 aged 20 years, P2 aged 28 years) with severe TBI and demonstrating psychological distress, as measured by the Depression Anxiety and Stress Scale (DASS- 588 Abstract Brain Inj …

Exploring The Relationship Between Cognitive Flexibility And Psychological Flexibility After Acquired Brain Injury, Diane L. Whiting, Frank Deane, Joseph Ciarrochi, Hamish Mcleod, Grahame Simpson

joseph Ciarrochi

Abstract presented at the Tenth World Congress on Brain Injury, 19-22 March 2014, San Francisco, United States

Changes In Visual And Sensory-Motor Resting-State Functional Connectivity Support Motor Learning By Observing., Heather R Mcgregor, Paul L Gribble

Brain and Mind Institute Researchers' Publications

Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153-160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493-1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289-2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989-994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, …

Relative Volume Of The Cerebellum In Dolphins And Comparison With Anthropoid Primates, L. Marino, James K. Rilling, Shinko K. Lin, Sam H. Ridgway

Lori Marino, PhD

According to the ‘developmental constraint hypothesis’ of comparative mammalian neuroanatomy, brain growth follows predictable allometric trends. Therefore, brain structures should scale to the entire brain in the same way across mammals. Evidence for a departure from this pattern for cerebellum volume has recently been reported among the anthropoid primates. One of the mammalian groups that has been neglected in tests of the ‘developmental constraint hypothesis’ is the cetaceans (dolphins, whales, and porpoises). Because many cetaceans possess relative brain sizes in the range of primates comparative tests of the ‘developmental constraint hypothesis’ across these two groups could help to delineate the …

Fusion Analysis Of Functional Mri Data For Classification Of Individuals Based On Patterns Of Activation., Mahdi Ramezani, Purang Abolmaesumi, Kris Marble, Heather Trang, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary information that may be available in multiple contrasts. Where multiple contrasts are used, the objective has been only to identify the joint, distinct brain activity patterns that differ between groups of subjects; not to use the information to classify individuals. Here, we use joint Independent Component Analysis (jICA) within a Support Vector Machine (SVM) classification …

Response To Susilo And Duchaine: Beyond Neuropsychological Dissociations In Understanding Face And Word Representations., David Plaut, Marlene Behrmann

Marlene Behrmann

No abstract provided.

Motor Skill Learning Between Selection And Execution., Jörn Diedrichsen, Katja Kornysheva

Brain and Mind Institute Researchers' Publications

Learning motor skills evolves from the effortful selection of single movement elements to their combined fast and accurate production. We review recent trends in the study of skill learning which suggest a hierarchical organization of the representations that underlie such expert performance, with premotor areas encoding short sequential movement elements (chunks) or particular component features (timing/spatial organization). This hierarchical representation allows the system to utilize elements of well-learned skills in a flexible manner. One neural correlate of skill development is the emergence of specialized neural circuits that can produce the required elements in a stable and invariant fashion. We discuss …

Distinctive Pattern Found In Ied Survivors’ Brains, News Brief

The Journal of Conventional Weapons Destruction

New research offers insight into brain trauma incurred by improvised explosive devices (IED), a problem affecting survivors of blast-related injuries since World War I.

Measuring The Plasticity Of Social Approach: A Randomized Controlled Trial Of The Effects Of The Peers Intervention On Eeg Asymmetry In Adolescents With Autism Spectrum Disorders, Amy V. Van Hecke, Sheryl Jayne Stevens, Audrey M. Carson, Jeffrey S. Karst, Bridget Dolan, Kirsten A. Schohl, Ryan J. Mckindles, Rheanna Remmel, Scott Brockman

Psychology Faculty Research and Publications

This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with …

Gross Morphological Brain Changes With Chronic, Heavy Cannabis Use, Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Daniel Lubman, Christos Pantelis, Murat Yücel

Faculty of Social Sciences - Papers (Archive)

We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe.

Functional Brain Network Classification With Compact Representation Of Sice Matrices, Jianjia Zhang, Luping Zhou, Lei Wang, Wanqing Li

Faculty of Engineering and Information Sciences - Papers: Part A

Recently, sparse inverse covariance estimation (SICE) technique has been employed to model functional brain connectivity. The inverse covariance matrix (SICE matrix in short) estimated for each subject is used as a representation of brain connectivity to discriminate Alzheimers disease from normal controls. However, we observed that direct use of the SICE matrix does not necessarily give satisfying discrimination, due to its high dimensionality and the scarcity of training subjects. Looking into this problem, we argue that the intrinsic dimensionality of these SICE matrices shall be much lower, considering i) an SICE matrix resides on a Riemannian manifold of symmetric positive …

Prolonged In Vivo Retention Of A Cathepsin D Targeted Optical Contrast Agent In A Mouse Model Of Alzheimer's Disease., Jonatan A Snir, Mojmir Suchy, Keith St Lawrence, Robert H E Hudson, Stephen H Pasternak, Robert Bartha

Brain and Mind Institute Researchers' Publications

BACKGROUND: Cathepsin D (CatD) is a lysosomal protease that is elevated early in Alzheimer's disease (AD). We have previously developed a Targeted contrast agent (CA) to detect CatD activity in vivo, consisting of a magnetic resonance imaging/fluorescent moiety linked to a cell penetrating peptide (CPP) by means of a CatD cleavage site and have demonstrated its uptake in the brain of an AD mouse model.

OBJECTIVE: The purpose of this study was to characterize the in vivo retention of a near infra-red fluorescent dye labeled version of this CA.

METHODS: Six adult C57Bl/6 wild-type mice and six adult 5XFAD transgenic …

Validating Measures Of Psychological Flexibility In A Population With Acquired Brain Injury, Diane L. Whiting, Frank P. Deane, Joseph Ciarrochi, Hamish J. Mcleod, Grahame K. Simpson

Faculty of Social Sciences - Papers (Archive)

This study presents preliminary validation data on both the Acceptance and Action Questionnaire—Acquired Brain Injury (AAQ-ABI) and the Acceptance and Action Questionnaire—II (AAQ-II). Data from 150 participants with ABI was subject to exploratory factor analysis on the AAQ-ABI (15 items). A subset of 75 participants with ABI completed a larger battery of measures to test construct validity for the AAQ-ABI and to undertake a confirmatory factor analysis (CFA) on the AAQ-II (7 items). Three meaningful factors were identified on the AAQ-ABI: Reactive Avoidance, Denial, and Active Acceptance. Reactive Avoidance demonstrated good internal and test–retest consistency (α = .89) and correlated …

Fusion Analysis Of First Episode Depression: Where Brain Shape Deformations Meet Local Composition Of Tissue., Mahdi Ramezani, Purang Abolmaesumi, Amir Tahmasebi, Rachael Bosma, Ryan Tong, Tom Hollenstein, Kate Harkness, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

Computational neuroanatomical techniques that are used to evaluate the structural correlates of disorders in the brain typically measure regional differences in gray matter or white matter, or measure regional differences in the deformation fields required to warp individual datasets to a standard space. Our aim in this study was to combine measurements of regional tissue composition and of deformations in order to characterize a particular brain disorder (here, major depressive disorder). We use structural Magnetic Resonance Imaging (MRI) data from young adults in a first episode of depression, and from an age- and sex-matched group of non-depressed individuals, and create …

Hemispheric Specialization For Emotion Within First And Second Languages : Emotion Word Processing In Monolingual And Bilingual Speakers, Jennifer Mary Martin

Legacy Theses & Dissertations (2009 - 2024)

Emotion representation in monolingual speakers is complex, and for bilinguals the relationship between emotion and language can be even more intriguing. The present study examined reactions to words of six types, including positive, negative, and neutral words varying in concreteness. Words and nonwords were intermixed in a lexical decision task using hemifield presentation. In Experiment 1, participants were English monolinguals and all stimuli were presented in English. In Experiment 2, participants were Spanish-English bilinguals who were presented with both English and Spanish stimuli. Results revealed a general left hemisphere advantage. Overall, reaction times for positive words were faster than for …