Social and Behavioral Sciences Commons^™

Ante- And Perinatal Risk Factors And Neuropsychological Outcome: Exploration Of The Role Of Multiple Birth And Acid-Base Status In Preterm Born Preschoolers, Jamie Piercy

Wayne State University Dissertations

Increased attention to medical risk factors that precede or accompany preterm birth is necessary in order to better understand functional deficits in this vulnerable population. Children who are born preterm are subject to increased risk of neurodevelopmental deficits in the preschool years and beyond. As such, the current study aimed to gain a better understanding of the influence of two disparate biological risk factors, one antenatal and the other perinatal, on neuropsychological development. More specifically, the influence of twin gestation and low arterial pH (reflecting hypoxic risk) on neuropsychological outcomes was examined in a sample of preterm-born (before 34-weeks gestation) …

Emotion Perception Correlates In Moderate And Severe Traumatic Brain Injury, Rachel Keelan

Wayne State University Dissertations

Introduction: Studies have demonstrated that individuals with TBI experience impairments in emotion perception accuracy in facial and auditory modalities but does not yet understand patterns of emotion perception and their relation to neurocognitive performance. The current study assessed why emotion perception deficits occur via psychological and cognitive relationships as well as patterns of emotion misattributions.

Methods: 50 adults with a bona-fide moderate or severe traumatic brain injury and 39 healthy comparison adults were included in the study. Eligible participants completed a battery of paper-and-pencil and computerized neuropsychological measures, including three tasks of emotion perception, and psychological questionnaires.

Results: The TBI …

Motor Skills Among Preschool-Aged Children Born Prematurely, Brittany Nicole Peters

Wayne State University Dissertations

It has been documented that children who are born prematurely are at risk of experiencing motor skills deficits early in life; however, little is known about the relationships between early perinatal risk factors and later motor abilities. The current investigation attempted to gain better understanding regarding the influence of gestational age and sex on early motor development among a cohort of preschool-aged children born prior to 34 weeks gestation (N = 104). Additionally, relationships between motor performance and other abilities, namely cognitive and language, were examined. As hypothesized, degree of gestational immaturity was significantly associated with poorer performance on specific …

Twin Gestation And Neuropsychological Outcome Of Preschool Age Children Born Prematurely, Jamie Christine Piercy

Wayne State University Theses

Multiples are thought to be at increased risk for developmental outcome deficits in the preschool years, following preterm birth. However, little research has been conducted to determine whether this group remains at higher risk in the age of artificial reproductive techniques and the modern NICU. The purpose of this study was to investigate whether multiplicity is a risk factor for neuropsychological outcome deficits in a sample of 118 preschoolers (49 multiples, 75 singletons) born prematurely (<34 weeks gestation). As predicted, there were significant relationships between multiplicity and outcome measures, however, the direction of the effects were opposite to our prediction, with multiplies demonstrating superior performance. Additionally, significant multiplicity by sex interactions revealed a female twin advantage over male twin and singleton performance. In this preschool age sample, preterm multiples were not at a disadvantage when compared to singleton counterparts, demonstrating either equivalent or superior neuropsychological performance.

Antidepressant Medications And Cognitive Functioning In Major Depressive Disorder, Rachel Kay

Wayne State University Theses

Individuals with Major Depressive Disorder (MDD) frequently experience cognitive decrements in addition to mood impairments. Ironically, antidepressant medications used to treat depression may have adverse effects on cognitive functioning. It is imperative to understand the relative cognitive costs of antidepressants when considering the treatment of MDD patients. Furthermore, observational studies of depression are challenged by problems of systematically confounded variables. Researchers are often faced with difficulties in managing this issue and opt to either ignore the problem, alter their sample, or use inappropriate statistical methods (e.g., Analysis of Covariance) due to a limited understanding of acceptable solutions. It is important …

Assessment Of Memory Function And Effort Using The Wechsler Memory Scale - 4th Edition, Justin B. Miller

Wayne State University Dissertations

Even the most psychometrically sound measures are sensitive to the level of effort put forth by the examinee and their intent. This is especially true for measures of memory functioning that are a common target of negative response bias and withholding effort. The aim of the present study was to develop methods for detecting these behaviors for the current edition of the Wechsler Memory Scale, 4th Edition (WMS-IV) using a community sample of healthy adults coached to simulate traumatic brain injury (TBI) and a sample of bona fide TBI survivors. The primary analytic strategy involved generation of prediction models to …