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Full-Text Articles in Social and Behavioral Sciences
Biodegradable Prefabricated Vertical Drains: From Laboratory To Field Studies, Thanh Trung Nguyen, Buddhima Indraratna, Pankaj Baral
Biodegradable Prefabricated Vertical Drains: From Laboratory To Field Studies, Thanh Trung Nguyen, Buddhima Indraratna, Pankaj Baral
Faculty of Engineering and Information Sciences - Papers: Part B
Biodegradable prefabricated vertical drains (BPVDs) made from natural fibres have been in use for several decades to improve soft soil, especially in East and Southeast Asia despite the fact that this type of drain has still not been fully addressed and evaluated. This study presents a series of laboratory tests where a drain made from coconut cores wrapped in Indian jute sheath filters is compared to conventional synthetic prefabricated vertical drains (SPVDs). Discharge volume tests are carried out with and without soil clogging to understand how jute drains can resist soil clogging under increasing confining pressure. Along with these macro-hydraulic …
Post‐Marketing Studies Of Pharmaceutical Opioid Abuse‐Deterrent Formulations: A Framework For Research Design And Reporting, Amy Peacock, Briony K. Larance, Raimondo Bruno, Sallie-Anne Pearson, Nicholas A. Buckley, Michael P. Farrell, Louisa Degenhardt
Post‐Marketing Studies Of Pharmaceutical Opioid Abuse‐Deterrent Formulations: A Framework For Research Design And Reporting, Amy Peacock, Briony K. Larance, Raimondo Bruno, Sallie-Anne Pearson, Nicholas A. Buckley, Michael P. Farrell, Louisa Degenhardt
Faculty of Social Sciences - Papers (Archive)
Background and aims Opioid formulations with properties to deter abuse (abuse‐deterrent formulations; ADFs) have been developed as one response to the prescription opioid 'epidemic'. As for all medicines, ADFs undergo evaluation of safety and efficacy prior to registration for marketing. However, reduced extra‐medical use (the primary intended outcome of ADFs and reason for their introduction) can only be established in post‐marketing observational studies, comparing them to opioid formulations without abuse‐deterrent properties. This has implications for various features of study design and analysis. We discuss proposals for the design, conduct, governance and reporting of post‐marketing studies on the effectiveness of pharmaceutical …
Experimental And Numerical Studies Of Square Concrete-Filled Double Steel Tubular Short Columns Under Eccentric Loading, Mizen Ahmed, Qing Quan Liang, Vipulkumar I. Patel, Muhammad N. S Hadi
Experimental And Numerical Studies Of Square Concrete-Filled Double Steel Tubular Short Columns Under Eccentric Loading, Mizen Ahmed, Qing Quan Liang, Vipulkumar I. Patel, Muhammad N. S Hadi
Faculty of Engineering and Information Sciences - Papers: Part B
Square concrete-filled double steel tubular (CFDST) beam-columns consisting of an internal circular steel tube have increasingly been utilized in composite building structures because of their high structural performance. This paper describes experimental and numerical studies on the structural responses of square thin-walled CFDST columns loaded eccentrically. Tests on twenty short square CFDST columns were undertaken that included sixteen columns under eccentric loading and four columns under concentric loading. The parameters examined in the experiments included the cross-sectional dimensions, the width-to-thickness ratios of outer and internal tubes and loading eccentricity. The measured ultimate strengths, load-shortening responses, load-lateral displacement curves, stress-strain curves …
Two Studies Of The Empirical Basis Of Two Learning Resource-Oriented Motivational Strategies For Gifted Educators, Anamaria Vladut, Wilma Vialle, Albert Ziegler
Two Studies Of The Empirical Basis Of Two Learning Resource-Oriented Motivational Strategies For Gifted Educators, Anamaria Vladut, Wilma Vialle, Albert Ziegler
Faculty of Social Sciences - Papers (Archive)
Two learning resource-oriented motivational strategies for gifted educators are introduced: a homeostatic orientation that aims for balance and an allostatic orientation that aims at growth. In order to establish the empirical basis of these motivational strategies, two studies were conducted with samples of students from a specialized post-secondary business school who were enrolled in grades 11–13. Study 1 focused on the empirical basis of the homeostatic orientation. It was shown that the availability of learning resources is associated with two forms of balance within an actiotope: robustness and resilience. Furthermore, it could be shown that the effects of exogenous learning …
Cjcheck Stage 1: Development And Testing Of A Checklist For Reporting Community Juries - Delphi Process And Analysis Of Studies Published In 1996-2015, Rae Thomas, Rebecca Sims, Christopher J. Degeling, Jackie M. Street, Stacy M. Carter, Lucie Rychetnik, Jenny Whitty, Andrew Wilson, Paul Ward, Paul Glasziou
Cjcheck Stage 1: Development And Testing Of A Checklist For Reporting Community Juries - Delphi Process And Analysis Of Studies Published In 1996-2015, Rae Thomas, Rebecca Sims, Christopher J. Degeling, Jackie M. Street, Stacy M. Carter, Lucie Rychetnik, Jenny Whitty, Andrew Wilson, Paul Ward, Paul Glasziou
Faculty of Social Sciences - Papers (Archive)
Background Opportunities for community members to actively participate in policy development are increasing. Community/citizen's juries (CJs) are a deliberative democratic process aimed to illicit informed community perspectives on difficult topics. But how comprehensive these processes are reported in peer‐reviewed literature is unknown. Adequate reporting of methodology enables others to judge process quality, compare outcomes, facilitate critical reflection and potentially repeat a process. We aimed to identify important elements for reporting CJs, to develop an initial checklist and to review published health and health policy CJs to examine reporting standards. Design Using the literature and expertise from CJ researchers and policy …
Cancer Beliefs In Ethnic Minority Populations: A Review And Meta-Synthesis Of Qualitative Studies, Sharon Licqurish, Lyn Phillipson, Peggy Chiang, Jennifer Walker, Fiona Walter, Jon Emery
Cancer Beliefs In Ethnic Minority Populations: A Review And Meta-Synthesis Of Qualitative Studies, Sharon Licqurish, Lyn Phillipson, Peggy Chiang, Jennifer Walker, Fiona Walter, Jon Emery
Faculty of Social Sciences - Papers (Archive)
People from ethnic minorities often experience poorer cancer outcomes, possibly due to later presentation to healthcare and later diagnosis. We aimed to identify common cancer beliefs in minority populations in developed countries, which can affect symptom appraisal and help seeking for symptomatic cancer. Our systematic review found 15 relevant qualitative studies, located in the United Kingdom (six), United States (five), Australia (two) and Canada (two) of African, African-American, Asian, Arabic, Hispanic and Latino minority groups. We conducted a meta-synthesis that found specific emotional reactions to cancer, knowledge and beliefs and interactions with healthcare services as contributing factors in help seeking …
Cognitive And Oculomotor Performance In Subjects With Low And High Schizotypy: Implications For Translational Drug Development Studies, Ivan Koychev, D Joyce, Emma Barkus, Ulrich Ettinger, Anne Schmechtig, Colin Dourish, Gerard Dawson, Kevin Craig, John Francis Deakin
Cognitive And Oculomotor Performance In Subjects With Low And High Schizotypy: Implications For Translational Drug Development Studies, Ivan Koychev, D Joyce, Emma Barkus, Ulrich Ettinger, Anne Schmechtig, Colin Dourish, Gerard Dawson, Kevin Craig, John Francis Deakin
Faculty of Social Sciences - Papers (Archive)
The development of drugs to improve cognition in patients with schizophrenia is a major unmet clinical need. A number of promising compounds failed in recent clinical trials, a pattern linked to poor translation between preclinical and clinical stages of drug development. Seeking proof of efficacy in early Phase 1 studies in surrogate patient populations (for example, high schizotypy individuals where subtle cognitive impairment is present) has been suggested as a strategy to reduce attrition in the later stages of drug development. However, there is little agreement regarding the pattern of distribution of schizotypal features in the general population, creating uncertainty …
Performance Improvement Of Rail Track Substructure Using Artificial Inclusions - Experimental And Numerical Studies, Buddhima Indraratna, Sanjay Nimbalkar, Ngoc Trung Ngo, Tim Neville
Performance Improvement Of Rail Track Substructure Using Artificial Inclusions - Experimental And Numerical Studies, Buddhima Indraratna, Sanjay Nimbalkar, Ngoc Trung Ngo, Tim Neville
Faculty of Engineering and Information Sciences - Papers: Part A
Large and frequent loads from heavy freight and passenger trains often lead to the progressive track deterioration. The excessive deformation and degradation of ballast and unacceptable differential settlement of track and/or pumping of underlying soft subgrade soils necessitates frequent and costly track maintenance. However, artificial inclusions such as geogrids and shockmats can mitigate ballast degradation and improve track performance. A quantitative assessment of the influence of breakage, fouling, and the effects of artificial inclusions on the shear behaviour of ballast can be performed either experimentally or numerically. Numerical modelling can simulate these aspects subject to various types of loading and …
Implications Of Proxy Efficacy For Studies Of Team Leadership In Organizational Settings, Seyyed B. Alavi, John Mccormick
Implications Of Proxy Efficacy For Studies Of Team Leadership In Organizational Settings, Seyyed B. Alavi, John Mccormick
Faculty of Social Sciences - Papers (Archive)
Although there have been numerous studies of self-efficacy and collective efficacy in different contexts, little attention has been paid to proxy efficacy. In this article we propose that a person's self-efficacy may be related to proxy efficacy when achievement of personal goals is related to the performance of the proxy on the person's behalf. We argue this is important in team leadership. We further propose that the extent to which team members believe their leaders efficacious as their proxies may affect team processes and effectiveness. A team level construct, namely team proxy efficacy for the leader, referring to a shared …
The Case Studies: Chat In Use - Case Study 13.1 Designing An Effective Undergraduate Vocal Pedagogy Environment: A Case Of Cultural-Historical Activity Approach In A Singing Course, Irina Verenikina, Lotte Latukefu
The Case Studies: Chat In Use - Case Study 13.1 Designing An Effective Undergraduate Vocal Pedagogy Environment: A Case Of Cultural-Historical Activity Approach In A Singing Course, Irina Verenikina, Lotte Latukefu
Faculty of Social Sciences - Papers (Archive)
This chapter draws on six case studies of pedagogy with technology in Higher Education. The studies are chosen because they illustrate how the use of technology impacts on pedagogy in these contexts. While the cases are drawn from different levels of higher education (undergraduate to postgraduate) they are woven together by a shared framework: namely, the use of CHAT to explore pedagogical innovation with technology. One of the significant strengths of CHAT, all studies will argue, lies in its ability to situate goal-directed action within the larger context of a motive-directed activity. That is, its explanatory power lies in situating …
A Revisit Of Three Studies Related To Random Testing, Tsong Yueh Chen, Fei-Ching Kuo, Dave Towey, Zhiquan Zhou
A Revisit Of Three Studies Related To Random Testing, Tsong Yueh Chen, Fei-Ching Kuo, Dave Towey, Zhiquan Zhou
Faculty of Engineering and Information Sciences - Papers: Part A
© 2015 Science China Press and Springer-Verlag Berlin Heidelberg Software testing is an approach that ensures the quality of software through execution, with a goal being to reveal failures and other problems as quickly as possible. Test case selection is a fundamental issue in software testing, and has generated a large body of research, especially with regards to the effectiveness of random testing (RT), where test cases are randomly selected from the software’s input domain. In this paper, we revisit three of our previous studies. The first study investigated a sufficient condition for partition testing (PT) to outperform RT, and …
In Situ Powder Diffraction Studies Of Electrode Materials In Rechargeable Batteries, Neeraj Sharma, Wei Kong Pang, Zaiping Guo, Vanessa K. Peterson
In Situ Powder Diffraction Studies Of Electrode Materials In Rechargeable Batteries, Neeraj Sharma, Wei Kong Pang, Zaiping Guo, Vanessa K. Peterson
Faculty of Engineering and Information Sciences - Papers: Part A
The ability to directly track the charge carrier in a battery as it inserts/extracts from an electrode during charge/discharge provides unparalleled insight for researchers into the working mechanism of the device. This crystallographic-electrochemical information can be used to design new materials or modify electrochemical conditions to improve battery performance characteristics, such as lifetime. Critical to collecting operando data used to obtain such information insitu while a battery functions are X-ray and neutron diffractometers with sufficient spatial and temporal resolution to capture complex and subtle structural changes. The number of operando battery experiments has dramatically increased in recent years, particularly those …
3d Bridge Microdosimeter: Charge Collection Study And Application To Rbe Studies In 12C Radiation Therapy, Linh T. Tran, Dale A. Prokopovich, Susanna Guatelli, Marco Petasecca, Michael L. F Lerch, Mark I. Reinhard, Anatoly B. Rosenfeld
3d Bridge Microdosimeter: Charge Collection Study And Application To Rbe Studies In 12C Radiation Therapy, Linh T. Tran, Dale A. Prokopovich, Susanna Guatelli, Marco Petasecca, Michael L. F Lerch, Mark I. Reinhard, Anatoly B. Rosenfeld
Faculty of Engineering and Information Sciences - Papers: Part A
Radiotherapy using heavy ion beam such as Carbon-ion has the advantage for the treatment of deep-seated tumour over conventional radiotherapy with X-rays due to an enhanced dose deposition in the Bragg peak (BP) at the end of the ion range. The highest dose can be deposited in the tumour with much lower doses to the surrounding healthy tissue. The Relative Biological Effectiveness (RBE) of a carbon-ion radiotherapy beam greatly depends on a depth of the target volume in the body and the nuclear fragmentation process that increases close to the BP or spread out BP (SOBP) as well as neutrons. …
Studies Consistently Find No Academic Gains From Private Schooling, But Don't Explain Why, Ian M. Brown
Studies Consistently Find No Academic Gains From Private Schooling, But Don't Explain Why, Ian M. Brown
Faculty of Social Sciences - Papers (Archive)
I have a vivid primary school memory of playing with another child of similar age who cautioned, "Sister told us not to play with the publics." The public-private divide still exists today with ongoing debates about funding struggles, comparisons of the quality of infrastructure, values, standards and discipline being discussed and compared. There is a perception among parents that they will help their children do better academically if they send them to a non-government school. Lately, a new debate has surged with the comparison of educational outcomes questioning which system produces the better student. When weighing up such serious financial …
Case Studies On Response Of Laterally Loaded Nonlinear Piles, Wei Dong Guo
Case Studies On Response Of Laterally Loaded Nonlinear Piles, Wei Dong Guo
Faculty of Engineering and Information Sciences - Papers: Part A
Closed-form solutions for laterally loaded free and fixed-head piles in elastic-plastic media have been developed and implemented into a spreadsheet program called GASLFP. Underpinned by a generic limiting force profile (LFP), the solutions offer an expeditious and sufficiently accurate method for predicting response of lateral piles. They also allow parameters to be deduced using measured pile response, as is evident in the study to date on -70 test (elastic) piles. The solutions also well capture the impact of structure nonlinearity of pile body by employing reduced pile bending stiffness (EpIp). The law of the reduction in EpIp, however, needs to …
Five Practical Uses Of Spatial Autocorrelation For Studies Of Coral Reef Ecology, S Hamylton
Five Practical Uses Of Spatial Autocorrelation For Studies Of Coral Reef Ecology, S Hamylton
Faculty of Science, Medicine and Health - Papers: part A
The organisation of benthic communities across coral reefs is underpinned by spatially structured ecological processes and neighbourhood interactions such as larval dispersal, migration, competition and the spread of disease. These give rise to spatial autocorrelation in reef communities. This paper demonstrates how the measurement of spatial autocorrelation can profitably be incorporated into studies of coral reef ecology through a series of 5 simple statistical exercises: for the generation of maps depicting the strength of spatial relationships between ecological communities, as an indicator of optimal dimensions for sampling ecological communities on coral reefs, as a diagnostic tool for model misspecification, as …
Escherichia Coli Single-Stranded Dna-Binding Protein: Nanoesi-Ms Studies Of Salt-Modulated Subunit Exchange And Dna Binding Transactions, Claire E. Mason, Slobodan Jergic, Allen Lo, Yao Wang, Nicholas E. Dixon, Jennifer L. Beck
Escherichia Coli Single-Stranded Dna-Binding Protein: Nanoesi-Ms Studies Of Salt-Modulated Subunit Exchange And Dna Binding Transactions, Claire E. Mason, Slobodan Jergic, Allen Lo, Yao Wang, Nicholas E. Dixon, Jennifer L. Beck
Faculty of Science, Medicine and Health - Papers: part A
Single-stranded DNA-binding proteins (SSBs) are ubiquitous oligomeric proteins that bind with very high affinity to single-stranded DNA and have a variety of essential roles in DNA metabolism. Nanoelectrospray ionization mass spectrometry (nanoESI-MS) was used to monitor subunit exchange in full-length and truncated forms of the homotetrameric SSB from Escherichia coli. Subunit exchange in the native protein was found to occur slowly over a period of hours, but was significantly more rapid in a truncated variant of SSB from which the eight C-terminal residues were deleted. This effect is proposed to result from C-terminus mediated stabilization of the SSB tetramer, in …
Studies Of The Surface Reaction Mechanisms Of Pb-3 Wt%Sn-0.5 Wt%Ag Anode In Cro3 Solutions, Jianzhong Li, Xiuli Sun, Yanwen Tian, Yue Zhao
Studies Of The Surface Reaction Mechanisms Of Pb-3 Wt%Sn-0.5 Wt%Ag Anode In Cro3 Solutions, Jianzhong Li, Xiuli Sun, Yanwen Tian, Yue Zhao
Faculty of Engineering and Information Sciences - Papers: Part A
This work examines the change of surface properties and the reaction process of lead alloy anode in CrO3 solution under conditions of high current density, by means of SEM, EDX, XRD, electrochemical test and Raman spectroscopy, for understanding the corrosion mechanism of lead alloy anode. In the initial oxidation stage of lead alloy anode, the diffraction peaks of monoclinic PbCrO4 and PbO are clearly shown in the XRD spectrum of the lead alloy surface. With increasing reaction time, PbCrO4 and PbO diffraction peaks are weakened and those of lead dioxide strengthened. Cyclic voltammetry reveals that the electrode potential change is …
Performance Monitoring Of Rail Tracks Stabilized By Geosynthetics And Shock Mats: Case Studies At Bulli And Singleton In Australia, Buddhima Indraratna, Sanjay Nimbalkar, Pongpipat Anantanasakul, Cholachat Rujikiatkamjorn, Tim Neville
Performance Monitoring Of Rail Tracks Stabilized By Geosynthetics And Shock Mats: Case Studies At Bulli And Singleton In Australia, Buddhima Indraratna, Sanjay Nimbalkar, Pongpipat Anantanasakul, Cholachat Rujikiatkamjorn, Tim Neville
Faculty of Engineering and Information Sciences - Papers: Part A
Rail tracks are conventionally built on compacted ballast and structural fill embankments overlying the natural subsoil. Ballast plays an important role in providing track stiffness to support heavy traffic loads, and providing rapid drainage. However, ballast deforms and degrades progressively under the heavy cyclic loading of passenger and freight trains, which may lead to a loss of track geometry, and require costly regular maintenance. In particular, track construction requires appropriate stabilization techniques for ballast, the extent of which depends also on the type of subgrade. Comprehensive field trials were carried out on two rail lines in Bulli and recently in …
Analyzing Weight Loss Intervention Studies With Missing Data: Which Method Should Be Used?, Marijka J. Batterham, Linda C. Tapsell, Karen E. Charlton
Analyzing Weight Loss Intervention Studies With Missing Data: Which Method Should Be Used?, Marijka J. Batterham, Linda C. Tapsell, Karen E. Charlton
Faculty of Science, Medicine and Health - Papers: part A
Objective: Missing data due to study dropout is common in weight loss trials and several statistical methods exist to account for it. The aim of this study was to identify methods in the literature and to compare the effects of methods of analysis using simulated data sets. Methods: Literature was obtained for a 1-y period to identify analytical methods used in reporting weight loss trials. A comparison of methods with large or small between-group weight loss, and missing data that was, or was not, missing randomly was conducted in simulated data sets based on previous research. Results: Twenty-seven studies, some …
Teaching About Diverse Families Through Case Studies And Authentic Performance Assessment, Amy Conley Wright
Teaching About Diverse Families Through Case Studies And Authentic Performance Assessment, Amy Conley Wright
Faculty of Social Sciences - Papers (Archive)
Authentic performance assessment connects active learning pedagogy with assessment of student learning. For family sciences, authentic performance assessment presents an opportunity to evaluate knowledge and skills related to working with families within the classroom context. This form of assessment can be combined with popular teaching strategies, like using family case studies, to provide application and context for course content. This article reviews the literature on authentic performance assessment and its application in the family science literature, and provides an example of an authentic performance assessment in a course on understanding and working with diverse families. The discussion provides suggestions for …
Integrating Fluent Pronunciation Use Into Content-Based Esl Instruction: Two Case Studies, Amanda Baker
Integrating Fluent Pronunciation Use Into Content-Based Esl Instruction: Two Case Studies, Amanda Baker
Faculty of Social Sciences - Papers (Archive)
This paper examines the teaching practices of two ESL teachers who integrated pronunciation instruction into intermediate-level, content/task-based, oral communication courses in an Intensive English program. These practices are analysed according to five categories of pronunciation instruction: Language Awareness; Controlled Practice; Guided Practice, Fluency Development and Free Practice. The fourth category, Fluency Development, is defined based on the work of Nation and Newton (2009), who list, among several criteria, pressure to perform at greater speeds or at least "more smoothly" as central to improving learner fluency. Based on classroom observations, interviews with teachers and student questionnaires, the degree to which the …
Validly Measuring Destination Image In Survey Studies, Sara Dolnicar, Bettina Grun
Validly Measuring Destination Image In Survey Studies, Sara Dolnicar, Bettina Grun
Faculty of Commerce - Papers (Archive)
Destination image is among the most frequently measured constructs in empirical survey research. Academic tourism researchers tend to use multi-category scales, often referring to them as "Likert scales," while industry typically uses "pickany" measures. But which leads to results that are more valid? Findings from a large-scale experimental study show that a "forced-choice full binary" format (where respondents have to tick "yes" and "no" for each destination-attribute combination) performs better than both current preferred formats in academic and applied studies.
Translocation Of The Eastern Bristlebird 2: Applying Principles To Two Case Studies, Jack Baker, David Bain, Jean Clarke, Kris French
Translocation Of The Eastern Bristlebird 2: Applying Principles To Two Case Studies, Jack Baker, David Bain, Jean Clarke, Kris French
Faculty of Science, Medicine and Health - Papers: part A
The Eastern Bristlebird (Dasyornis brachypterus) is an endangered endemic passerine of south-eastern Australia. The re-establishment of extirpated populations through translocation was identified as a key action in New South Wales to address the threats to this species associated with habitat fragmentation and widespread and frequent fire. At Jervis Bay during 2003-2005, 50 birds were translocated from Bherwerre Peninsula to Beecroft Peninsula. In the Illawarra in 2008, 50 birds were translocated from Barren Grounds Nature Reserve to Cataract. At Jervis Bay, monitoring indicated that after 7 years, (i) there was no detectable impact on the source population from the removal of …
Fish Consumption And Chd Mortality: An Updated Meta-Analysis Of Seventeen Cohort Studies, Jusheng Zheng, Tao Huang, Yinghua Yu, Xiaojie Hu, Bin Yang, Duo Li
Fish Consumption And Chd Mortality: An Updated Meta-Analysis Of Seventeen Cohort Studies, Jusheng Zheng, Tao Huang, Yinghua Yu, Xiaojie Hu, Bin Yang, Duo Li
Faculty of Health and Behavioural Sciences - Papers (Archive)
Objective Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects. Design A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity. Setting PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study. Subjects Seventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified. Results …
Phytochemical And Biological Activity Studies Of The Bhutanese Medicinal Plant Corydalis Crispa, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan
Phytochemical And Biological Activity Studies Of The Bhutanese Medicinal Plant Corydalis Crispa, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan
Faculty of Science - Papers (Archive)
The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.
Model Studies Towards The Total Synthesis Of The Stemona Alkaloid 1-Hydroxyprotostemonine: Synthesis Of Ent-1-Hydroxystemoamide, Nalivela Kumara Swamy, Stephen G. Pyne
Model Studies Towards The Total Synthesis Of The Stemona Alkaloid 1-Hydroxyprotostemonine: Synthesis Of Ent-1-Hydroxystemoamide, Nalivela Kumara Swamy, Stephen G. Pyne
Faculty of Science, Medicine and Health - Papers: part A
As part of a model study towards the total synthesis of Stemona alkaloid 1-hydroxyprotostemonine 1, we have achieved the synthesis an A-B-C ring precursor, ent-1-hydroxystemoamide. Key steps involve an ene-yne RCM reaction and a diastereoselective dihydroxylation-lactonization reaction.
"Pick-Any" Measures Contaminate Brand Image Studies, Sara Dolnicar, John R. Rossiter, Bettina Grun
"Pick-Any" Measures Contaminate Brand Image Studies, Sara Dolnicar, John R. Rossiter, Bettina Grun
Faculty of Commerce - Papers (Archive)
Brand image measures using the typical "pick-any" answer format have been shown to be unstable (Rungie et al., 2005). In the present study, we find that the poor stability results are mainly caused by the pick-any measure itself because it allows consumers to evade reporting true associations. Using a forced-choice binary measure, we find that stable brand attribute associations are in fact present with much higher incidence (70%), thus outperforming both the measures predominantly used in industry (pick-any, 41%) and academia (7-point scale measure, 59%). Under simulated optimal conditions the forced-choice binary measure leads to 90% stability of brand-attribute associations …
Electronic Interactions Within Composites Of Polyanilines Formed Under Acidic And Alkaline Conditions. Conductivity, Esr, Raman, Uv-Vis And Fluorescence Studies, L Dennany, P C. Innis, S T. Mcgovern, Gordon G. Wallace, Robert J. Forster
Electronic Interactions Within Composites Of Polyanilines Formed Under Acidic And Alkaline Conditions. Conductivity, Esr, Raman, Uv-Vis And Fluorescence Studies, L Dennany, P C. Innis, S T. Mcgovern, Gordon G. Wallace, Robert J. Forster
Faculty of Science - Papers (Archive)
The properties of two forms of polyaniline (PAni) synthesised under acidic and basic conditions have been investigated both individually and as combined complexes. The PAni polymerised within alkaline media was redox inactive and non-conducting while the PAni emeraldine salt (ES) was electroactive and conducting. Raman, electron spin resonance, UV-Vis and fluorescence spectroscopies were used to monitor the changes in electronic properties of these conducting polymer composites. Solution cast films of alkaline synthesised (A-PAni) with the PAni ES resulted in an increase in the high spin polaron population suggesting that it acts as a pseudodopant. The ability of the A-PAni to …
Single Molecule Studies Of Physiologically Relevant Telomeric Tails Reveal Pot1 Mechanism For Promoting G-Quadruplex Unfolding, Hong Wang, Gerald J. Nora, Harshad Ghodke, Patricia L. Opresko
Single Molecule Studies Of Physiologically Relevant Telomeric Tails Reveal Pot1 Mechanism For Promoting G-Quadruplex Unfolding, Hong Wang, Gerald J. Nora, Harshad Ghodke, Patricia L. Opresko
Faculty of Science, Medicine and Health - Papers: part A
Human telomeres are composed of duplex TTAGGG repeats and a 3' single-stranded DNA tail. The telomeric DNA is protected and regulated by the shelterin proteins, including the protection of telomeres 1 (POT1) protein that binds telomeric single-stranded DNA. The single-stranded tail can fold into G-quadruplex (G4) DNA. Both POT1 and G4 DNA play important roles in regulating telomere length homeostasis. To date, most studies have focused on individual quadruplexes formed by four TTAGGG repeats. Telomeric tails in human cells have on average six times as many repeats, and no structural studies have examined POT1 binding in competition with G4 DNA …