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Articles 1 - 13 of 13
Full-Text Articles in Social and Behavioral Sciences
Ballistic Missiles In China's Anti-Taiwan Blockade Strategy, Christopher Rahman
Ballistic Missiles In China's Anti-Taiwan Blockade Strategy, Christopher Rahman
Chris Rahman
No abstract provided.
Predicting The Effectiveness Of Anti-Speeding Tv Advertisements By Skin Conductance Response (Scr), Jennifer Thornton, John R. Rossiter
Predicting The Effectiveness Of Anti-Speeding Tv Advertisements By Skin Conductance Response (Scr), Jennifer Thornton, John R. Rossiter
John Rossiter
The purpose of this study is to determine whether the Hopkins and Fletcher (1994) ad-testing measure - which uses skin conductance response (SCR) to predict the effectiveness of sales messages for commercial products and services - would be similarly predictive for road safety ads. The predictive ability of SCR was tested on four pairs of anti-speeding ads using a behavioural dependent measure of speed choice. Overall, there was a weak correlation between SCR scores and speed choice scores (r = -.116, p < .10), and this was largely due to a strong correlation for one of the eight ads tested Further …
Targeting Urokinase And The Transferrin Receptor With Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death And Reduces Tumor Growth, K Vine, V. Indira Chandran, J Locke, L Matesic, J Lee, D Skropeta, J Bremner, M Ranson
Targeting Urokinase And The Transferrin Receptor With Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death And Reduces Tumor Growth, K Vine, V. Indira Chandran, J Locke, L Matesic, J Lee, D Skropeta, J Bremner, M Ranson
Danielle Skropeta
Tumor-specific delivery of ligand-directed prodrugs can increase the therapeutic window of chemotherapeutics by maintaining efficacy whilst decreasing toxic side effects. We have previously described a series of synthetic N-alkylated isatin cytotoxins that destabilize microtubules and induce apoptosis with 10-fold greater potency than conventional anti-mitotics in vitro. Here, we report the characterization, in vitro cytotoxicity and in vivo efficacy of a lead compound, 5,7-dibromo-N-(p-hydroxymethylbenzyl)isatin (N-AI) conjugated via an esterase-labile linker (N-AIE) to two proven targeting ligands, transferrin (Tf) and plasminogen activator inhibitor type 2 (PAI-2/serpinB2). N-AI was released from N-AIE and the targeting ligands Tf/PAI-2 in an esterase-dependent manner at 37 …
Anti-Cancer Activity Of An Acid-Labile N-Alkylisatin Conjugate Targeting The Transferrin Receptor, Vineesh Indira Chandran, Lidia Matesic, Julie Locke, Danielle Skropeta, Marie Ranson, Kara Vine
Anti-Cancer Activity Of An Acid-Labile N-Alkylisatin Conjugate Targeting The Transferrin Receptor, Vineesh Indira Chandran, Lidia Matesic, Julie Locke, Danielle Skropeta, Marie Ranson, Kara Vine
Danielle Skropeta
We have previously reported a series of pH-sensitive imine-linked N-alkylisatin prodrugs that are stable at pH 7.4, but readily cleaved at pH 4.5. Herein, one of the most potent prodrugs, 5,7-dibromo-N-(pmethoxybenzyl) isatin (NAI), was functionalized with a para-phenylpropionic acid linker, and the resulting NAI–imine prodrug conjugated to transferrin (Tf) to form a NAI–imine–Tf conjugate. Cytotoxicity assays revealed the conjugate was equipotent to the free drug against MCF-7 breast cancer cells, with clear selectivity patterns based on TfR levels. These results suggest that this novel isatin-based cytotoxin conjugated to a tumor targeting protein via an acid-labile linker warrants further preclinical testing.
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Danielle Skropeta
To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.
Revealing Indigenous Indonesian Traditional Medicine: Anti-Infective Agents, Paul A. Keller, Ari Satia Nugraha
Revealing Indigenous Indonesian Traditional Medicine: Anti-Infective Agents, Paul A. Keller, Ari Satia Nugraha
Paul Keller
Indonesia is rich in medicinal plants which the population has used traditionally from generation to generation for curing diseases. Our interest in the treatment of infectious diseases has lead to the investigation of traditional Indonesian treatments. In this review, we present a comprehensive review of ethnopharmacologically directed screening in Indonesian medicinal plants to search for new anti-viral, antimalarial, anti-bacterial and anti-fungal agents. Some potent drug leads have been isolated from Indonesian medicinal plants. Further research is still required for the lead development as well as the search for new bioactive compounds from the enormous medicinal plant resources.
Replication Termination In Escherichia Coli: Structure And Anti-Helicase Activity Of The Tus-Ter Complex, Cameron Neylon, Andrew V. Kralicek, Thomas M. Hill, Nicholas E. Dixon
Replication Termination In Escherichia Coli: Structure And Anti-Helicase Activity Of The Tus-Ter Complex, Cameron Neylon, Andrew V. Kralicek, Thomas M. Hill, Nicholas E. Dixon
Professor Nick E Dixon
The arrest of DNA replication in Escherichia coli is triggered by the encounter of a replisome with a Tus protein-Ter DNA complex. A replication fork can pass through a Tus-Ter complex when traveling in one direction but not the other, and the chromosomal Ter sites are oriented so replication forks can enter, but not exit, the terminus region. The Tus-Ter complex acts by blocking the action of the replicative DnaB helicase, but details of the mechanism are uncertain. One proposed mechanism involves a specific interaction between Tus-Ter and the helicase that prevents further DNA unwinding, while another is that the …
Somewhere Between Anti-Heroism And Pantomime: Song Kang-Ho And The Uncanny Face Of The Korean Cinema, Brian Yecies
Somewhere Between Anti-Heroism And Pantomime: Song Kang-Ho And The Uncanny Face Of The Korean Cinema, Brian Yecies
Brian Yecies
This article explores the trajectory of Song Kang-ho’s on-screen performances from the release of his fourth film, Number 3 (1997), to one of his most recent films, Thirst (2009). As a case study, it reveals new insights about this popular and representative actor’s numerous screen personae and how they have enabled audiences to peer into a cinematic surface that reflects back a mixture of anti-heroism and pantomime. Beneath the many costumes and performance styles he adopts, audiences have come to see a human being with everyday problems and concerns. In a way reminiscent of the French pantomime clown Pierrot, Song’s …
Somewhere Between Anti-Heroism And Pantomime: Song Kang-Ho And The Uncanny Face Of The Korean Cinema, Brian Yecies
Somewhere Between Anti-Heroism And Pantomime: Song Kang-Ho And The Uncanny Face Of The Korean Cinema, Brian Yecies
Brian Yecies
This article explores the trajectory of Song Kang-ho’s on-screen performances from the release of his fourth film, Number 3 (1997), to one of his most recent films, Thirst (2009). As a case study, it reveals new insights about this popular and representative actor’s numerous screen personae and how they have enabled audiences to peer into a cinematic surface that reflects back a mixture of anti-heroism and pantomime. Beneath the many costumes and performance styles he adopts, audiences have come to see a human being with everyday problems and concerns. In a way reminiscent of the French pantomime clown Pierrot, Song’s …
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Xu-Feng Huang
Background: In addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate how simvastatin impacts on experimental parkinsonian models via regulating NMDA receptors. Methodology/Principal Findings: Regional changes in NMDA receptors in the rat brain and anxiolytic-like activity were examined after unilateral medial forebrain bundle lesion by 6-hydroxydopamine via a 3-week administration of simvastatin. NMDA receptor alterations in the post-mortem rat brain were detected by [3H]MK-801(Dizocilpine) binding autoradiography. 6-hydroxydopamine treated PC12 was applied …
Advertising Wearout Of Shock-Value Anti-Speeding Ads, Jennifer Thornton, John R. Rossiter
Advertising Wearout Of Shock-Value Anti-Speeding Ads, Jennifer Thornton, John R. Rossiter
John Rossiter
An advertising experiment was conducted to test the advertising wearout of four anti-speeding ads, each with varying underlying "patterns" of fear arousal. The patterns of fear were established beforehand by using a dial designed to track viewers’ reactions in terms of tenseness felt. The advertising experiment involved 284 participants from a first-year University marketing class. Four experimental groups were exposed to the same antispeeding ad each week, for three sequential weeks. Measures were obtained, via a questionnaire, of the participants’ attention paid to the ad, expected effect on speeding behaviour, emotions felt, perceptions of the relevance, believability, realism of the …
Initiatives On Ip Enforcement Beyond Trips: The Anti-Counterfeiting Trade Agreement And The International Medical Products Anti-Counterfeiting Task Force, Christoph Antons, Gabriel Garcia
Initiatives On Ip Enforcement Beyond Trips: The Anti-Counterfeiting Trade Agreement And The International Medical Products Anti-Counterfeiting Task Force, Christoph Antons, Gabriel Garcia
Dr Gabriel Garcia
No abstract provided.
Organisational Perspectives On Anti-Doping Work In Sport, Alanah Kazlauskas, Helen M. Hasan
Organisational Perspectives On Anti-Doping Work In Sport, Alanah Kazlauskas, Helen M. Hasan
Helen Hasan
The diverse challenges associated with anti-doping work in sport can result in multiple, competing viewpoints amongst stakeholder groups working to solve the problem. Coupled with the complexity of the problem itself, this has the potential to generate chaotic or disordered work contexts that impede rather than promote progress towards a solution. A visible lack of progress can be magnified to a public perception of anti-doping work as ineffective. We offer the Cynefin Framework, informed by Complexity Theory, as a novel theoretical and methodological lens for sense-making in the changing global context of anti-doping work. The framework’s applicability at both individual …