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Meal Parameters And Vagal Gastrointestinal Afferents In Mice That Experienced Early Postnatal Overnutrition, Jessica Biddinger, Edward A. Fox

Department of Psychological Sciences Faculty Publications

Early postnatal overnutrition disrupts satiety without altering vagal gastrointestinal afferents. PHYSIOL BEHAV 00(0) 000-000, 2010. Early postnatal overnutrition results in a predisposition to develop obesity due in part to hypothalamic and sympathetic dysfunction. Potential involvement of another major regulatory system component - the vagus nerve - has not been examined. Moreover, feeding disturbances have rarely been investigated prior to development of obesity when confounds due to obesity are minimized. To examine these issues, litters were culled on the day of birth to create small litters (SL; overnutrition), or normal-size litters (NL; normal nutrition). Body weight, fat pad weight, meal patterns, …