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Full-Text Articles in Social and Behavioral Sciences
Age Differences In The Frontal Lateralization Of Verbal And Spatial Working Memory Revealed By Pet, Alan Hartley, Patricia A. Reuter-Lorenz, John Jonides, Edward E. Smith, Andrea Miller, Christina Marshuetz, Robert A. Koeppe
Age Differences In The Frontal Lateralization Of Verbal And Spatial Working Memory Revealed By Pet, Alan Hartley, Patricia A. Reuter-Lorenz, John Jonides, Edward E. Smith, Andrea Miller, Christina Marshuetz, Robert A. Koeppe
Scripps Faculty Publications and Research
Age-related decline in working memory figures prominently in theories of cognitive aging. However, the effects of aging on the neural substrate of working memory are largely unknown. Positron emission tomography (PET) was used to investigate verbal and spatial short-term storage (3 sec) in older and younger adults. Previous investigations with younger subjects performing these same tasks have revealed asymmetries in the lateral organization of verbal and spatial working memory. Using volume of interest (VOI) analyses that specifically compared activation at sites identified with working memory to their homologous twin in the opposite hemisphere, we show pronounced age differences in this …